Nature Search

Inflammatory monocytes promote granuloma control of Yersinia infection

Enteric Yersinia pseudotuberculosis infection is contained by host inflammatory monocyte-driven pyogranuloma formation to counter bacterial YopH-dependent anti-neutrophil activity.

Daniel Sorobetea
Rina Matsuda
Igor E. Brodsky
Research06 Mar 2023
Nature Microbiology

Volume: 8, P: 666-678
Transcriptional control of the Cryptosporidium life cycle

The transcription factor Myb-M is the earliest determinant of male fate in the parasite Cryptosporidium parvum.

Katelyn A. Walzer
Jayesh Tandel
Boris Striepen
Research29 May 2024
Nature

Volume: 630, P: 174-180
Targeting PARP11 to avert immunosuppression and improve CAR T therapy in solid tumors

Fuchs and colleagues delineate a mechanism by which PARP11-mediated IFNAR1 loss sustains an immunosuppressive tumor microenvironment and show that PARP11 inactivation can enhance chimeric antigen receptor T efficacy in preclinical solid tumor models.

Hongru Zhang
Pengfei Yu
Serge Y. Fuchs
Research30 May 2022
Nature Cancer

Volume: 3, P: 808-820
The maternal vaginal microbiome partially mediates the effects of prenatal stress on offspring gut and hypothalamus

Maternal stress during pregnancy is a risk factor for neurodevelopmental disorders. Jasarevic and colleagues show that the maternal vaginal microbiota partially mediates the lasting effects of prenatal stress on the gut and hypothalamus in mice.

Eldin Jašarević
Christopher D. Howard
Tracy L. Bale
Research09 Jul 2018
Nature Neuroscience

Volume: 21, P: 1061-1071
Life cycle progression and sexual development of the apicomplexan parasite Cryptosporidium parvum

Infection with Cryptosporidium parvum is a leading cause of severe diarrhoeal disease and childhood mortality worldwide. Using tools they recently developed to genetically engineer Cryptosporidium, the authors define life cycle stage-specific markers and generate reporter parasites, making life cycle progression and parasite sex tractable.

Jayesh Tandel
Elizabeth D. English
Boris Striepen
ResearchOpen Access02 Sept 2019
Nature Microbiology

Volume: 4, P: 2226-2236
Activation of p38α stress-activated protein kinase drives the formation of the pre-metastatic niche in the lungs

Gui et al. report that tumor-cell-derived factors induce p38a activation in lung fibroblasts, leading to inactivation of type I interferon signaling, matrix remodeling and neutrophil infiltration, thereby generating a metastasis-permissive niche.

Jun Gui
Farima Zahedi
Serge Y. Fuchs
Research25 May 2020
Nature Cancer

Volume: 1, P: 603-619
Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence

Replication defective viral genomes (DVGs) can facilitate persistence of paramyxoviruses, but the underlying mechanisms are unclear. Using FISH, Xu et al. here analyze the cellular response to DVGs on a single cell level and show that a MAVS-mediated TNF response specifically extends survival of cells enriched in DVGs.

Jie Xu
Yan Sun
Carolina B. López
ResearchOpen Access06 Oct 2017
Nature Communications

Volume: 8, P: 1-13
Alarmin S100A11 initiates a chemokine response to the human pathogen Toxoplasma gondii

Yarovinsky and colleagues identify the alarmin S100A11, which is released from Toxoplasma gondii–infected cells, as the trigger for immune responses in humans. S100A11 induces expression of the chemokine CCL2, which recruits inflammatory CCR2⁺ monocytes to the sites of infection.

Alexandra Safronova
Alessandra Araujo
Felix Yarovinsky
Research19 Nov 2018
Nature Immunology

Volume: 20, P: 64-72
Author Correction: Involvement of Innate Immune System in Late Stages of Inherited Photoreceptor Degeneration

Raghavi Sudharsan
Daniel P. Beiting
William A. Beltran
Amendments and CorrectionsOpen Access14 Nov 2018
Scientific Reports

Volume: 8, P: 1
Enterocyte–innate lymphoid cell crosstalk drives early IFN-γ-mediated control of Cryptosporidium

Jodi A. Gullicksrud
Adam Sateriale
Christopher A. Hunter
Research08 Nov 2021
Mucosal Immunology

Volume: 15, P: 362-372
Stress during pregnancy alters temporal and spatial dynamics of the maternal and offspring microbiome in a sex-specific manner

Eldin Jašarević
Christopher D. Howard
Tracy L. Bale
ResearchOpen Access07 Mar 2017
Scientific Reports

Volume: 7, P: 1-13
Involvement of Innate Immune System in Late Stages of Inherited Photoreceptor Degeneration

Raghavi Sudharsan
Daniel P. Beiting
William A. Beltran
ResearchOpen Access20 Dec 2017
Scientific Reports

Volume: 7, P: 1-12

Search

Inflammatory monocytes promote granuloma control of Yersinia infection

Transcriptional control of the Cryptosporidium life cycle

Targeting PARP11 to avert immunosuppression and improve CAR T therapy in solid tumors

The maternal vaginal microbiome partially mediates the effects of prenatal stress on offspring gut and hypothalamus

Life cycle progression and sexual development of the apicomplexan parasite Cryptosporidium parvum

Activation of p38α stress-activated protein kinase drives the formation of the pre-metastatic niche in the lungs

Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence

Alarmin S100A11 initiates a chemokine response to the human pathogen Toxoplasma gondii

Author Correction: Involvement of Innate Immune System in Late Stages of Inherited Photoreceptor Degeneration

Enterocyte–innate lymphoid cell crosstalk drives early IFN-γ-mediated control of Cryptosporidium

Stress during pregnancy alters temporal and spatial dynamics of the maternal and offspring microbiome in a sex-specific manner

Involvement of Innate Immune System in Late Stages of Inherited Photoreceptor Degeneration

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