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The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI

Cellular senescence drives aging, with the p53–FOXO4 axis sustaining senescent cell viability. This study reveals structural insights into p53 binding to FOXO4/FOXO4-DRI, informing the development of p53-targeted senolytics for age related diseases.

Benjamin Bourgeois
Emil Spreitzer
Tobias Madl
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-17

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The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI

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