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Showing 1–6 of 6 results
Advanced filters: Author: Daniel Poeckel Clear advanced filters

  • The PI3K/Akt/mTOR pathway has been previously implicated in fibrosis and a pan-PI3K/mTOR inhibitor is currently under clinical evaluation for the treatment of IPF. Here the authors show that the mTORC1/4E-BP1 axis is critical for TGF-β1-induced fibrogenesis in in vitro and ex vivo models and that canonical PI3K/Akt signalling is dispensable.

    • Hannah V. Woodcock
    • Jessica D. Eley
    • Rachel C. Chambers
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • The proteome-wide characterization of proteostasis depends on robust approaches to determine protein half-lives. Here, the authors improve the accuracy and precision of mass spectrometry-based quantification, enabling reliable protein half-life determination in several non-dividing cell types.

    • Toby Mathieson
    • Holger Franken
    • Mikhail M. Savitski
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • Bantscheff et al. use chemoproteomics to measure the affinity of small molecules for megadalton protein complexes in cell extracts. Differences in the selectivity of HDAC inhibitors observed when native HDAC complexes are compared with their purified catalytic subunits suggest the limitations of using isolated recombinant proteins in certain drug screens.

    • Marcus Bantscheff
    • Carsten Hopf
    • Gerard Drewes
    Research
    Nature Biotechnology
    Volume: 29, P: 255-265

  • The use of a high-affinity VHL ligand allows the development of chimeric molecules that promote the association of ERRα or RIPK2 with the VHL E3 ubiquitin ligase complex, resulting in protein degradation.

    • Daniel P Bondeson
    • Alina Mares
    • Craig M Crews
    Research
    Nature Chemical Biology
    Volume: 11, P: 611-617