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Showing 1–7 of 7 results
Advanced filters: Author: Daniel Rehling Clear advanced filters

  • Stoldt, Maass, and colleagues present a study where smFISH is combined with STED and MINFLUX microscopy to map mitochondrial mRNA at nanometre resolution, enabling the exploration of the structural folding and distribution of mRNAs within mitochondria.

    • Stefan Stoldt
    • Frederike Maass
    • Stefan Jakobs
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11

  • The TOM and TIM23 complexes facilitate the transport of nuclear-encoded proteins into the mitochondrial matrix. Here, the authors use a stalled client protein to purify the translocation supercomplex and gain insight into the TOM-TIM23 interface and the mechanism of protein handover from the TOM to the TIM23 complex.

    • Ridhima Gomkale
    • Andreas Linden
    • Peter Rehling
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Cellular target engagement technologies enable quantification of intracellular drug binding, but the simultaneous assessment of drug-associated phenotypes is challenging. Here, the authors develop CeTEAM (cellular target engagement by accumulation of mutant), a platform that can simultaneously evaluate drug-target interactions and phenotypic responses for holistic assessment of drug pharmacology using conditionally stabilized drug biosensors.

    • Nicholas C. K. Valerie
    • Kumar Sanjiv
    • Mikael Altun
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-22

  • Nucleoside analogs (NNA), such as acyclovir (ACV) and ganciclovir (GCV), are widely used as anti-virals to treat herpes virus infection. Here, Nishii et al. show that diphosphatase NUDT15 hydrolyzes ACV and GCV, therewith reducing NNA activity in vitro and link NUDT15 variation to inter-patient variability in ACV and GCV therapeutic effects.

    • Rina Nishii
    • Takanori Mizuno
    • Jun J. Yang
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9

  • TH1760 is a first-in-class, potent, selective and cell-active inhibitor against human NUDT15, which sensitizes cells to 6-thioguanine treatment. TH1760 represents a valuable tool for deciphering the enigmatic functions of NUDT15.

    • Si Min Zhang
    • Matthieu Desroses
    • Thomas Helleday
    Research
    Nature Chemical Biology
    Volume: 16, P: 1120-1128

  • How translation termination is achieved for the non-conventional mtDNA-encoded COX1 and ND6 was so far unknown. Here, Nadler et al. address this question by assessing the functions and specificity of the mitochondrial release factors mtRF1 and mtRF1a.

    • Franziska Nadler
    • Elena Lavdovskaia
    • Ricarda Richter-Dennerlein
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • The white pupae (wp) phenotype has been used for decades to selectively remove females of tephritid species in genetic sexing, but the determining gene is unknown. Here, the authors show that wp phenotype is produced by parallel mutations in a Major Facilitator Superfamily domain containing gene across multiple species.

    • Christopher M. Ward
    • Roswitha A. Aumann
    • Marc F. Schetelig
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12