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Showing 1–10 of 10 results
Advanced filters: Author: Daniel Scheiermann Clear advanced filters

  • Neurotrophic factor Nerve Growth Factor (NGF) is involved in bladder physiopathology. Here the authors report that mast-cell derived NGF sustains the pro-tumoral functions of ILC2s in bladder cancer (BC), showing that selective targeting of the NGF receptor TrkA improves survival and response to immune checkpoint blockade in BC models.

    • Maryline Falquet
    • Hajar El Ahanidi
    • Camilla Jandus
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-18

  • It is hard to design quantum neural networks able to work with quantum data. Here, the authors propose a noise-robust architecture for a feedforward quantum neural network, with qudits as neurons and arbitrary unitary operations as perceptrons, whose training procedure is efficient in the number of layers.

    • Kerstin Beer
    • Dmytro Bondarenko
    • Ramona Wolf
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-6

  • Rhythmic trafficking of dendritic cells to the tumour draining lymph node governs a circadian response of tumour-antigen-specific CD8+ T cells that is dependent on the circadian expression of the co-stimulatory molecule CD80.

    • Chen Wang
    • Coline Barnoud
    • Christoph Scheiermann
    ResearchOpen Access
    Nature
    Volume: 614, P: 136-143

  • Immunofluorescence imaging and computational modelling are used to study the spatial distribution of different cell types within the haematopoietic stem cell (HSC) niche; findings show that quiescent HSCs associate specifically with small arterioles that are preferentially found in the endosteal bone marrow and are essential in maintaining this quiescence.

    • Yuya Kunisaki
    • Ingmar Bruns
    • Paul S. Frenette
    Research
    Nature
    Volume: 502, P: 637-643

  • Many chemotherapy drugs cause sensory nerve damage as well as long-lasting damage to hematopoietic regeneration in the bone marrow. Paul Frenette and his colleagues show that this hematopoietic damage is caused by injury to bone marrow sympathetic nerve fibers, disrupting the hematopoietic stem cell niche. These findings point to the potential of neuroprotective agents in preserving hematopoietic function in chemotherapy-treated patients with cancer.

    • Daniel Lucas
    • Christoph Scheiermann
    • Paul S Frenette
    Research
    Nature Medicine
    Volume: 19, P: 695-703

  • Two papers in this issue, by Bruns et al. and Zhao et al., show that megakaryocytes constitute a niche for hematopoietic stem cells in the mouse bone marrow and produce factors that regulate hematopoietic stem cell quiescence and proliferation.

    • Ingmar Bruns
    • Daniel Lucas
    • Paul S Frenette
    Research
    Nature Medicine
    Volume: 20, P: 1315-1320