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Showing 1–3 of 3 results
Advanced filters: Author: Daniel Shae Clear advanced filters

  • AML1-ETO is a fusion protein in which acetylation of lysine-43 is critical to leukemogenesis. Here, they show that TAF1 is required for AML1-ETO mediated gene expression such that it binds to acetylated AML1-ETO to facilitate the association of AML1-ETO with chromatin, and consequently, promotes leukemic self-renewal.

    • Ye Xu
    • Na Man
    • Stephen Nimer
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • In cells, WAVE protein, a central regulator of actin dynamics during cell motility, is constitutively incorporated into WAVE regulatory complex (WRC), is normally present in an inactive state and can be activated by a number of inputs. These authors present the structure and mechanistic analysis of WRC. The combined data reveal how the WAVE protein is inhibited within the WRC complex and provide mechanisms for WRC activation at the plasma membrane.

    • Zhucheng Chen
    • Dominika Borek
    • Michael K. Rosen
    Research
    Nature
    Volume: 468, P: 533-538