Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–11 of 11 results
Advanced filters: Author: Daniel W. Neef Clear advanced filters

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

    • Erola Pairo-Castineira
    • Konrad Rawlik
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 617, P: 764-768

  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103

  • Achieving a high quality of life within the biophysical limits of the planet is a significant challenge. This study quantifies the resource use associated with meeting basic human needs, compares it to downscaled planetary boundaries for over 150 nations and finds that no country meets its citizens’ basic needs sustainably.

    • Daniel W. O’Neill
    • Andrew L. Fanning
    • Julia K. Steinberger
    Research
    Nature Sustainability
    Volume: 1, P: 88-95

  • The sustainability discourse is at risk of remaining too shallow to achieve necessary change. This Perspective argues not just for a commitment to transdisciplinarity but also a deeper understanding of the capabilities and failings of science in understanding the relationship between the human and natural worlds.

    • Daniel Niles
    • Narifumi Tachimoto
    Reviews
    Nature Sustainability
    Volume: 1, P: 540-543

  • Huntington’s disease (HD) is caused by misfolding of mutant Htt protein. The authors find that in HD models, the decreased expression of heat shock transcription factor 1 that usually protects against protein misfolding, is in part caused by elevated CK2α’ kinase and Fbxw7 E3 ligase expression.

    • Rocio Gomez-Pastor
    • Eileen T. Burchfiel
    • Dennis J. Thiele
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-17

  • Neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease are associated with the accumulation of misfolded proteins, resulting in neuronal dysfunction and cell death. Thiele and colleagues discuss the therapeutic potential of combating protein misfolding by harnessing the natural cellular protein-folding machinery through pharmacological activation of heat shock transcription factor 1, the master regulator of chaperone protein expression.

    • Daniel W. Neef
    • Alex M. Jaeger
    • Dennis J. Thiele
    Reviews
    Nature Reviews Drug Discovery
    Volume: 10, P: 930-944

  • Induction of cardiac contractility, although desirable for restoring heart function, often has long-term detrimental effects. From studies on RKIP, an upstream regulator of β-adrenergic receptor signaling, Schmid et al. show that cardiac contractility in mice can be increased in a well-tolerated manner through the balanced activation of the β1 and β2 subtypes of the adrenergic receptor.

    • Evelyn Schmid
    • Stefan Neef
    • Kristina Lorenz
    Research
    Nature Medicine
    Volume: 21, P: 1298-1306