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Showing 1–4 of 4 results
Advanced filters: Author: Daniel Wikenheiser Clear advanced filters

  • McNamee et al. develop a theory of entorhinal–hippocampal processing. Distributed entorhinal input drives hippocampal activity between distinct statistical and dynamical regimes of activity, thereby unifying several empirical observations.

    • Daniel C. McNamee
    • Kimberly L. Stachenfeld
    • Samuel J. Gershman
    Research
    Nature Neuroscience
    Volume: 24, P: 851-862

  • Total cell cycle duration is a key hallmark of cancer initiation, and determines whether defects in apoptosis, senescence, immune surveillance, angiogenesis, DNA repair, polarity and proliferation lead to cancer development.

    • Danian Chen
    • Suying Lu
    • Rod Bremner
    ResearchOpen Access
    Nature
    Volume: 641, P: 1309-1318

  • Germinal center B cells can undergo rapid proliferation. Shlomchik and colleagues show that germinal center B cells, unlike other rapidly proliferating cells, do not depend on glycolysis, but rather increase their peroxisome content and rewire their cellular metabolism to exclusively utilize fatty acid oxidation for their energetic needs.

    • Florian J. Weisel
    • Steven J. Mullett
    • Mark J. Shlomchik
    Research
    Nature Immunology
    Volume: 21, P: 331-342

  • BCR signaling in naive B cells and in GC B cells differs. Shlomchik and colleagues report that GC B cells are ‘rewired’ in their Akt activation module, increasing p-T308 over p-S473, leading to increases of negative regulators of BCR signaling and ultimately higher thresholds for BCR activation.

    • Wei Luo
    • William Hawse
    • Mark J. Shlomchik
    Research
    Nature Immunology
    Volume: 20, P: 736-746