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Showing 1–3 of 3 results
Advanced filters: Author: Daniel Worroll Clear advanced filters

  • A carbon nanotube-based sensor was developed to monitor endolysosomal acidification events in live cells and in vivo. The technology enables a spatiotemporal measurement of endolysosomal pH and real-time tracking of the dynamics of autophagy in tumors.

    • Mijin Kim
    • Chen Chen
    • Daniel A. Heller
    Research
    Nature Chemical Biology
    Volume: 19, P: 1448-1457

  • The RNA binding protein MUSASHI-2 (MSI2) is a potential therapeutic target for acute myeloid leukemia. Here the authors identify a small molecule inhibitor of MSI2 and characterize its effects in a murine leukemia model.

    • Gerard Minuesa
    • Steven K. Albanese
    • Michael G. Kharas
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • Ada Gjyrezi et al. show that ddPCR can be used to accurately measure androgen receptor variant (AR-V) expression levels in single circulating tumor cells (CTCs) from prostate cancer patients. They show that current methods for isolating CTCs tend to underestimate the prevalence of AR-V and that a specific variant, AR-v567es, could be potentially used as a biomarker for an aggressive subtype of prostate cancer.

    • Ada Gjyrezi
    • Giuseppe Galletti
    • Paraskevi Giannakakou
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-9