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Showing 1–4 of 4 results

Advanced filters: Author: Daniela Fietz Clear advanced filters

Inherited defects of piRNA biogenesis cause transposon de-repression, impaired spermatogenesis, and human male infertility

piRNAs are small RNA molecules found primarily in the testes of mice and men. Stallmeyer et al. demonstrate that variants in specific genes can disrupt the formation of piRNAs, impairing spermatogenesis and causing human male infertility.

Birgit Stallmeyer
Clara Bühlmann
Frank Tüttelmann
ResearchOpen Access09 Aug 2024
Nature Communications

Volume: 15, P: 1-18
T cells in testicular germ cell tumors: new evidence of fundamental contributions by rare subsets

Rashidul Islam
Jannis Heyer
Daniela Fietz
ResearchOpen Access22 Apr 2024
British Journal of Cancer

Volume: 130, P: 1893-1903
DDX3Y is likely the key spermatogenic factor in the AZFa region that contributes to human non-obstructive azoospermia

Analysing genetic data from 1,655 men with non-obstructive azoospermia (NOA) reveals four independent loss-of-function variants in DDX3Y, suggesting that it is a key gene in the AZFa region and should be considered in diagnostic workflows for NOA.

Ann-Kristin Dicke
Adrian Pilatz
Frank Tüttelmann
ResearchOpen Access31 Mar 2023
Communications Biology

Volume: 6, P: 1-7
Re-visiting the Protamine-2 locus: deletion, but not haploinsufficiency, renders male mice infertile

Simon Schneider
Melanie Balbach
Hubert Schorle
ResearchOpen Access11 Nov 2016
Scientific Reports

Volume: 6, P: 1-13