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Showing 1–8 of 8 results
Advanced filters: Author: Daniela Huzly Clear advanced filters

  • A comparison of the repertoire of SARS-CoV-2-specific epitopes targeted by T cells induced by vaccination or natural infection reveals that T cells predominantly target non-spike epitopes in convalescent individuals, while there is a broader spike-specific CD8+ T-cell response in vaccinees. Despite differences in T-cell response, the targeted T-cell epitopes were conserved between the wild-type and Omicron variants in both groups.

    • Julia Lang-Meli
    • Hendrik Luxenburger
    • Christoph Neumann-Haefelin
    ResearchOpen Access
    Nature Microbiology
    Volume: 7, P: 675-679

  • Human transplantation with allogeneic donor organs results in non-matching of MHC and differential presentation of T cell antigens. Here the authors show that in a lung transplanted SARS-CoV-2 infected patient T cell responses generated from the host may not be able to recognise infected cells within the graft and this may contribute to virus persistence.

    • Jonas Fuchs
    • Vivien Karl
    • Björn C. Frye
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • During viral infections high levels of antibodies can form soluble immune complexes (sICs) with antigen and trigger Fcγ receptors (FcγR) leading to increased immunopathology. Here the authors measure FcγRs activation by sICs and consider how these may lead to excessive immunopathology during severe SARS-CoV-2 infection.

    • Jakob Ankerhold
    • Sebastian Giese
    • Valeria Falcone
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Antibodies against SARS-CoV-2 can be used to treat infections but there is a risk of driving viral resistance to antibodies. Here the authors characterise SARS-CoV-2 escape mutants from an immunocompromised patient treated with anti-SARS-CoV-2 antibodies using mouse protection studies and structural prediction.

    • Lena Jaki
    • Sebastian Weigang
    • Jonas Fuchs
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • In this prospective cohort study, authors follow 328 households in Germany with at least one confirmed SARS-CoV-2 infection and find that children are more likely to seroconvert without symptoms and have higher specific antibody levels that persist longer than in adults.

    • Hanna Renk
    • Alex Dulovic
    • Roland Elling
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11