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Showing 1–11 of 11 results
Advanced filters: Author: Daniela Moralli Clear advanced filters

  • Previous studies have used fluorescently labelled cells to demonstrate the incorporation of transplanted photoreceptor precursors into the mouse retina. Here, the authors show that fluorescent proteins are passed between the host and transplanted cells rather than migration of donor cells into the retina.

    • Mandeep S. Singh
    • Jasmin Balmer
    • Robert E. MacLaren
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-5

  • TRIM37 overexpression promotes centrosome dysfunction that drives genomic instability in breast cancer cell lines containing the recurrent 17q23 amplicon, revealing a vulnerability that can be targeted to eliminate cancer cells.

    • Zhong Y. Yeow
    • Bramwell G. Lambrus
    • Andrew J. Holland
    Research
    Nature
    Volume: 585, P: 447-452

  • Preece, Alghadban et al. explore the use of naturally sterile hybrids as an alternative to vasectomized males for the production of pseudopregnant female mice for embryo transfer. Sterile hybrids can contribute to the refinement of the procedure by avoiding a surgical intervention associated with pain and discomfort.

    • Chris Preece
    • Samy Alghadban
    • Benjamin Davies
    Research
    Lab Animal
    Volume: 50, P: 49-52

  • High-grade serous ovarian carcinoma is often associated with TP53 mutation and chromosomal instability (CIN). Here, the authors generate ex vivo cultures from biopsies and ascites of patients and perform characterization to evaluate CIN mechanisms and compare drug sensitivity with patient responses.

    • Louisa Nelson
    • Anthony Tighe
    • Stephen S. Taylor
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-18

  • The rare loss-of-function allele p.Arg138* in SLC30A8 (encoding ZnT8) mediates protection against type 2 diabetes (T2D) through promoting better insulin secretion and enhanced glucose responsiveness, suggesting ZnT8 as a target for T2D treatment.

    • Om Prakash Dwivedi
    • Mikko Lehtovirta
    • Leif Groop
    Research
    Nature Genetics
    Volume: 51, P: 1596-1606

  • PRDM9 is a DNA-binding protein that controls the position of double-strand breaks in meiosis, and the gene that encodes it is responsible for hybrid infertility between closely related mouse species; this hybrid infertility is eliminated by introducing the zinc-finger domain sequence from the human version of the PRDM9 gene, a change which alters both the position of double-strand breaks and the symmetry of PRDM9 binding and suggests that PRDM9 may have a more general but transient role in the early stages of speciation.

    • Benjamin Davies
    • Edouard Hatton
    • Peter Donnelly
    Research
    Nature
    Volume: 530, P: 171-176

  • Repo-Man is a chromosome-binding subunit of protein phosphatase 1 to regulate mitosis. Here, de Castro and colleagues show that Repo-Man also regulates heterochromatin during interphase, and regulates gene repression and chromatin organization.

    • Inês J. de Castro
    • James Budzak
    • Paola Vagnarelli
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16

  • The specificity of 53BP1 and its co-factors for particular DNA substrates during non-homologous end joining (NHEJ) derives from REV7–shieldin, a four-subunit DNA-binding complex that is required for REV7-dependent NHEJ but not for REV7-dependent DNA interstrand cross-link repair.

    • Hind Ghezraoui
    • Catarina Oliveira
    • J. Ross Chapman
    Research
    Nature
    Volume: 560, P: 122-127