The structures of 1,5-polyol-containing polyketide-derived natural products are notoriously difficult to determine using spectroscopic techniques due to spectral overlap and chemical shift degeneracy. Now, a blueprint for the structure determination of this class of natural products is reported, combining ultra-high-resolution NMR spectroscopy and synthesis to unveil the correct structure of caylobolide A.
- Malcolm R. P. George
- Max Deering
- Varinder K. Aggarwal
