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Showing 1–4 of 4 results
Advanced filters: Author: Danielle M. Townsley Clear advanced filters

  • An adjuvanted SARS-CoV-2 spike-ferritin nanoparticle vaccine can elicit antibodies with relatively broad sarbecovirus activity in non-human primates. Here, the authors isolate and structurally characterize several monoclonal antibodies providing insights into the targeted epitopes and broad reactivity.

    • Rajeshwer S. Sankhala
    • Kerri G. Lal
    • M. Gordon Joyce
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • A multimodal analysis of patients with 22 different immune-mediated monogenic diseases versus matched healthy controls leads to the development of the immune health metric, which could be implemented broadly to predict responses to aging, vaccination and other immune perturbations.

    • Rachel Sparks
    • Nicholas Rachmaninoff
    • John S. Tsang
    Research
    Nature Medicine
    Volume: 30, P: 2461-2472

  • Systemic sclerosis (SSc) is an autoimmune disease causing skin fibrosis and organ inflammation. Here the authors generate and analyze SSc skin single cell RNA sequencing data to propose contributions from both myofibroblasts and endothelial-to-mesenchymal -transitioning cells (EndoMT) to skin fibrosis, and to implicate the involvement of Hippo signaling pathways.

    • Feiyang Ma
    • Pei-Suen Tsou
    • Johann E. Gudjonsson
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17