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Showing 1–11 of 11 results
Advanced filters: Author: Danielle Tenen Clear advanced filters

  • A single-cell atlas of white adipose tissue from mouse and human reveals diverse cell types and similarities and differences across species and dietary conditions.

    • Margo P. Emont
    • Christopher Jacobs
    • Evan D. Rosen
    Research
    Nature
    Volume: 603, P: 926-933

  • Creatine can be used for thermogenesis in adipocytes. Here Kazak et al. show that creatine uptake is required to sustain this thermogenic pathway. Knockdown of the creatine transporter, CrT, in adipocytes decreases thermogenesis and energy expenditure, whereas creatine supplementation increases energy expenditure in mice fed a high-fat diet.

    • Lawrence Kazak
    • Janane F. Rahbani
    • Bruce M. Spiegelman
    Research
    Nature Metabolism
    Volume: 1, P: 360-370

  • Ageing is associated with clonal hematopoiesis of indeterminate potential (CHIP), which is linked to increased risks of hematological malignancies. Here the authors uncover an epigenetic mechanism through which mutant p53 drives clonal hematopoiesis through interaction with EZH2.

    • Sisi Chen
    • Qiang Wang
    • Yan Liu
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • RNA interference screens were used to identify chromatin-associated factors that impede reprogramming of somatic cells into iPS cells; suppression of the chromatin assembly factor CAF-1 enhances the generation of iPS cells by rendering chromatin more accessible to pluripotency transcription factors.

    • Sihem Cheloufi
    • Ulrich Elling
    • Konrad Hochedlinger
    Research
    Nature
    Volume: 528, P: 218-224

  • The authors summarize the data produced by phase III of the Encyclopedia of DNA Elements (ENCODE) project, a resource for better understanding of the human and mouse genomes.

    • Federico Abascal
    • Reyes Acosta
    • Zhiping Weng
    ResearchOpen Access
    Nature
    Volume: 583, P: 699-710

  • The hypothalamic arcuate–median eminence (Arc-ME) complex is rich with functionally distinct cell types, a fraction of which have been characterized. The authors profile 20,921 individual cells by single-cell RNA-seq, identifying 50 Arc-ME cell types and their markers, determining each's response to energy status and implicating two neuron populations in the genetic control of obesity.

    • John N Campbell
    • Evan Z Macosko
    • Linus T Tsai
    Research
    Nature Neuroscience
    Volume: 20, P: 484-496

  • The authors summarize the history of the ENCODE Project, the achievements of ENCODE 1 and ENCODE 2, and how the new data generated and analysed in ENCODE 3 complement the previous phases.

    • Federico Abascal
    • Reyes Acosta
    • Richard M. Myers
    Reviews
    Nature
    Volume: 583, P: 693-698