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Showing 1–2 of 2 results
Advanced filters: Author: Daniil Vakhrameev Clear advanced filters

  • S1P5 is a sphingosine-1-phosphate (S1P) receptor implicated in immune and neurodegenerative disorders. Here, authors report a crystal structure of the S1P5 receptor in complex with a selective inverse agonist, revealing an allosteric subpocket and shedding light on inverse agonism in S1P receptors.

    • Elizaveta Lyapina
    • Egor Marin
    • Vadim Cherezov
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • Lushpa et al report the structure and dynamics of the TLR1 toll-interleukin like (TIR) cytoplasmic domain in both crystal and solution. They demonstrate that the TLR1 TIR domain is capable of specific binding of Zn with nanomolar affinity, which appears to be critical for receptor activation, and provide potential structures TLR1-TIR/Zn complex based on in silico data.

    • Vladislav A. Lushpa
    • Marina V. Goncharuk
    • Konstantin S. Mineev
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-12