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Showing 1–3 of 3 results
Advanced filters: Author: Danuta M. Jeziorska Clear advanced filters

  • Micro Capture-C allows physical contacts to be determined at base-pair resolution, revealing that transcription factors have an important role in the maintenance of the contacts between enhancers and promoters.

    • Peng Hua
    • Mohsin Badat
    • James O. J. Davies
    Research
    Nature
    Volume: 595, P: 125-129

  • RUNX1 is a large and complex gene with two alternative promoters and multiple hematopoietic enhancers. Here the authors show that unlike smaller genes Runx1 becomes sub-compartmentalized during differentiation and gene activation. This subcompartmentalization partially depends on CTCF binding at promoter-proximal CTCF sites and transcription.

    • Dominic D. G. Owens
    • Giorgio Anselmi
    • Marella F. T. R. de Bruijn
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Globin loci harbor genes that are expressed embryonically and silenced postnatally. Here the authors show that zeta-globin silencing depends upon selective hypoacetylation of its TAD subdomain, which blocks its interaction with the alpha-globin super-enhancer, and zeta-globin can be reactivated by acetylation.

    • Andrew J. King
    • Duantida Songdej
    • Christian Babbs
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15