Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–9 of 9 results
Advanced filters: Author: Daoyuan Qian Clear advanced filters

  • pH is a critical regulator of (bio)chemical processes and therefore tightly regulated in nature. Now, proteins have been shown to possess the functionality to drive pH gradients without requiring energy input or membrane enclosure but through condensation. Protein condensates can drive unique pH gradients that modulate biochemical activity in both living and artificial systems.

    • Hannes Ausserwöger
    • Rob Scrutton
    • Tuomas P. J. Knowles
    ResearchOpen Access
    Nature Chemistry
    P: 1-12

  • Biomolecular phase separation arises from collective molecular interactions and is emerging as a key theme for biological function. Here the authors propose a broadly applicable method to quantify these interactions based on compositional and energetic parameters.

    • Hannes Ausserwöger
    • Ella de Csilléry
    • Tuomas P. J. Knowles
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Biomolecular condensates can contain multiple phases. The number of droplets of each phase and their location give the condensate a certain architecture. Here the authors present a method to create a range of transient architectures in biomolecular condensates, making the architecture or interfacial area controllable design variables in experiments.

    • Nadia A. Erkamp
    • Madelief A. M. Verwiel
    • Tuomas P. J. Knowles
    ResearchOpen Access
    Nature Chemical Engineering
    Volume: 1, P: 430-439

  • Biomolecular condensates with internal structure allow cells to further organise their processes. In this work the authors investigate how condensates can obtain an internal structure with droplets of dilute phase inside via kinetic, rather than purely thermodynamic driving forces.

    • Nadia A. Erkamp
    • Tomas Sneideris
    • Tuomas P. J. Knowles
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-8

  • In this work the authors describe antimicrobial peptides (AMPs)-driven phase transitions of intracellular nucleic acids, whereby AMPs induce compaction and phase separation of nucleic acids, resulting in their sequestration and eventual cell death.

    • Tomas Sneideris
    • Nadia A. Erkamp
    • Tuomas P. J. Knowles
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Amyloid formation is an important class of protein self-assembly behaviour that is linked to functional processes and disease. This Review describes amyloid formation through the lens of general phase transitions, building on both classical and non-classical nucleation theories to illuminate fundamental molecular mechanisms underlying this phenomenon.

    • Thomas C. T. Michaels
    • Daoyuan Qian
    • Tuomas P. J. Knowles
    Reviews
    Nature Reviews Physics
    Volume: 5, P: 379-397