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Showing 1–5 of 5 results
Advanced filters: Author: Daphna Fenel Clear advanced filters

  • Heparan sulfates are long and complex polysaccharides that mediate a large number of biological processes at the cell surface. Here, the authors provide structural and functional insights into the human EXT1-EXT2 complex that carries out the polymerization of heparan sulfate chains.

    • Francisco Leisico
    • Juneina Omeiri
    • Rebekka Wild
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • An environmentally safe means of mosquito control is the application of Bacillus thuringiensis israelensis, which produces a cocktail of four naturally crystalline proteins exclusively toxic to mosquito. Here the authors report the atomic-resolution structures of Bti Cry11Aa and related Btj Cry11Ba solved de novo through Serial Femtosecond Crystallography on naturally-occurring nanocrystals.

    • Guillaume Tetreau
    • Michael R. Sawaya
    • Jacques-Philippe Colletier
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • Integrated kinetic and structural investigations reveal that the ubiquitous co-chaperonin prefoldin interacts with its coiled-coil helices on the islet amyloid polypeptide fibril surface and fibril ends to inhibit fibril elongation and secondary nucleation.

    • Ricarda Törner
    • Tatsiana Kupreichyk
    • Jerome Boisbouvier
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Bacillus thuringiensis israelensis (Bti) produces the naturally-crystalline proteinaceous toxin Cyt1Aa that is toxic to mosquito larvae. Here the authors grow recombinant nanocrystals of the Cyt1Aa protoxin in vivo and use serial femtosecond crystallography to determine its structure at different redox and pH conditions and by combining their structural data with further biochemical, toxicological and biophysical analyses provide mechanistic insights into the Cyt1Aa bioactivation cascade.

    • Guillaume Tetreau
    • Anne-Sophie Banneville
    • Jacques-Philippe Colletier
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16