Nature Search

Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations

The burden of asthma varies between ancestries, but GWAS have so far focused on mainly European ancestry populations. Here, Daya et al. perform GWAS for asthma in 14,654 individuals of African ancestry and, besides confirming previously known loci, identify two potentially African ancestry-specific loci.

Michelle Daya
Nicholas Rafaels
Maria Yazdanbakhsh
ResearchOpen Access20 Feb 2019
Nature Communications

Volume: 10, P: 1-13
A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome

The Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) aims to better understand population genetics of the African diaspora. Here, it uses deeply sequenced whole-genomes to describe the impact of admixture and potential disease burden of deleterious variants.

Rasika Ann Mathias
Margaret A. Taub
Kathleen C. Barnes
ResearchOpen Access11 Oct 2016
Nature Communications

Volume: 7, P: 1-10
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

The authors perform meta-analysis of GWAS studies for asthma from multiancestral cohorts. They identify five new loci and find that the asthma-associated loci are enriched near enhancer marks in immune cells.

Florence Demenais
Patricia Margaritte-Jeannin
Dan L. Nicolae
Research22 Dec 2017
Nature Genetics

Volume: 50, P: 42-53
Author Correction: Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations

Michelle Daya
Nicholas Rafaels
Maria Yazdanbakhsh
Amendments and CorrectionsOpen Access04 Sept 2019
Nature Communications

Volume: 10, P: 1-2
Metabolic response to extended continuous positive airway pressure in premature infants

Philip L. Ballard
Kelvin D. MacDonald
Cindy T. McEvoy
ResearchOpen Access22 Dec 2025
Pediatric Research

P: 1-11
Recombination rates in admixed individuals identified by ancestry-based inference

John Novembre and colleagues present a new approach for constructing recombination maps based on ancestry switch points among individuals. They construct a high-resolution genome-wide recombination map based on admixed African-American and African-Caribbean individuals and compare this to previous recombination maps.

Daniel Wegmann
Darren E Kessner
John Novembre
Research20 Jul 2011
Nature Genetics

Volume: 43, P: 847-853
Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry

Personalized medicine requires accurate and ethnicity-optimized reference genome panels. Here, the Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) evaluates typical variant filters and existing genome databases against newly sequenced African-ancestry populations.

Michael D. Kessler
Laura Yerges-Armstrong
Timothy D. O’Connor
ResearchOpen Access11 Oct 2016
Nature Communications

Volume: 7, P: 1-8
Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse

Jun Yang and colleagues show that common variants in GATA3 are associated with risk of Ph-like acute lymphoblastic leukemia (ALL). They further show that these variants are associated with variation in GATA3 expression levels and with risk of ALL relapse.

Virginia Perez-Andreu
Kathryn G Roberts
Jun J Yang
Research20 Oct 2013
Nature Genetics

Volume: 45, P: 1494-1498
Correction: Genetic variation in CRHR1 is associated with short-term respiratory response to corticosteroids in preterm infants at risk for bronchopulmonary dysplasia

Tamorah Lewis
William Truog
Dara Torgerson
Amendments and Corrections07 Feb 2019
Pediatric Research

Volume: 85, P: 731
Efficacy and feasibility of the BREATHE asthma intervention with American Indian children: a randomized controlled trial

Rae A. O’Leary
Marcia A. O’Leary
Lyle G. Best
ResearchOpen Access08 Dec 2022
Scientific Reports

Volume: 12, P: 1-9
A genome-wide association and admixture mapping study of bronchodilator drug response in African Americans with asthma

Melissa L. Spear
Donglei Hu
Esteban G. Burchard
Research12 Sept 2018
The Pharmacogenomics Journal

Volume: 19, P: 249-259
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations

Dan Nicolae, Carole Ober and colleagues report a meta-analysis of genome-wide association studies for asthma in a collection of ethnically diverse North American populations. They identify a newly associated susceptibility locus at PYHIN1 in individuals of African descent.

Dara G Torgerson
Elizabeth J Ampleford
Dan L Nicolae
Research31 Jul 2011
Nature Genetics

Volume: 43, P: 887-892
The hydrocortisone-responsive urinary metabolome of premature infants

Dara Torgerson
Miguel Guardado
Philip L. Ballard
ResearchOpen Access03 May 2023
Pediatric Research

Volume: 94, P: 1317-1326
Blood metabolomics in infants enrolled in a dose escalation pilot trial of budesonide in surfactant

Philip L. Ballard
Dara Torgerson
Cindy T. McEvoy
Research19 Jan 2021
Pediatric Research

Volume: 90, P: 784-794
Genetic variation in CRHR1 is associated with short-term respiratory response to corticosteroids in preterm infants at risk for bronchopulmonary dysplasia

Tamorah Lewis
William Truog
Dara Torgerson
Research22 Nov 2018
Pediatric Research

Volume: 85, P: 625-633
Identifying tagging SNPs for African specific genetic variation from the African Diaspora Genome

Henry Richard Johnston
Yi-Juan Hu
Maria Yazdanbakhsh
ResearchOpen Access21 Apr 2017
Scientific Reports

Volume: 7, P: 1-9

Search

Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations

A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Author Correction: Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations

Metabolic response to extended continuous positive airway pressure in premature infants

Recombination rates in admixed individuals identified by ancestry-based inference

Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry

Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse

Correction: Genetic variation in CRHR1 is associated with short-term respiratory response to corticosteroids in preterm infants at risk for bronchopulmonary dysplasia

Efficacy and feasibility of the BREATHE asthma intervention with American Indian children: a randomized controlled trial

A genome-wide association and admixture mapping study of bronchodilator drug response in African Americans with asthma

Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations

The hydrocortisone-responsive urinary metabolome of premature infants

Blood metabolomics in infants enrolled in a dose escalation pilot trial of budesonide in surfactant

Genetic variation in CRHR1 is associated with short-term respiratory response to corticosteroids in preterm infants at risk for bronchopulmonary dysplasia

Identifying tagging SNPs for African specific genetic variation from the African Diaspora Genome

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