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Advanced filters: Author: Daria Bunina Clear advanced filters

Histone H3.3 lysine 9 and 27 control repressive chromatin at cryptic enhancers and bivalent promoters

In this study, the authors mutate histone H3.3 K9 and K27 residues, demonstrating their importance in maintaining repressive chromatin states at endogenous retrovirus-derived cryptic enhancers and bivalent promoters in mouse embryonic stem cells.

Matteo Trovato
Daria Bunina
Kyung-Min Noh
ResearchOpen Access30 Aug 2024
Nature Communications

Volume: 15, P: 1-21
Distinct roles for MNK1 and MNK2 in social and cognitive behavior through kinase-specific regulation of the synaptic proteome and phosphoproteome

Rosalba Olga Proce
Maria Steinecker
Hanna Hörnberg
ResearchOpen Access13 Feb 2026
Molecular Psychiatry

P: 1-16
Lysine 4 of histone H3.3 is required for embryonic stem cell differentiation, histone enrichment at regulatory regions and transcription accuracy

Replacement of lysine 4 or 36 with alanine in histone H3.3 impairs ESC differentiation and induces widespread gene expression changes. Expression of H3.3K4A, but not H3.3K36A, leads to H3.3 depletion, reduces remodeler binding and increases RNA polymerase II activity.

Maja Gehre
Daria Bunina
Kyung-Min Noh
Research05 Mar 2020
Nature Genetics

Volume: 52, P: 273-282

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