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Showing 1–2 of 2 results
Advanced filters: Author: Daria Miroshnychenko Clear advanced filters

  • Although tumours evolve in a Darwinian fashion, they do not undergo sexual reproduction. The authors show experimentally and using mathematical modelling that spontaneous fusion between cancer cells allows recombination between clones and the possibility of exploring larger areas of the adaptive landscape.

    • Daria Miroshnychenko
    • Etienne Baratchart
    • Andriy Marusyk
    Research
    Nature Ecology & Evolution
    Volume: 5, P: 379-391

  • Acquired resistance to cancer therapies reflects the ability of cancers to adapt to therapy-imposed selective pressures. Here, the authors elucidate the dynamics of developing resistance to ALK inhibitors in an ALK+ lung cancer cell line showing that resistance originates from drug-specific tolerant cancer cells and it develops as a gradual adaptation.

    • Robert Vander Velde
    • Nara Yoon
    • Andriy Marusyk
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13