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Showing 1–4 of 4 results
Advanced filters: Author: Daria Shlyueva Clear advanced filters

  • Enhancers are DNA elements that are key regulators of gene expression, but their complexities and context dependence makes their identification and characterization challenging. This Review discusses how an improved understanding of the varied properties of enhancers is being used in diverse approaches for the systematic prediction of enhancers genome wide.

    • Daria Shlyueva
    • Gerald Stampfel
    • Alexander Stark
    Reviews
    Nature Reviews Genetics
    Volume: 15, P: 272-286

  • Naïve pluripotency is characterized by distinctly open chromatin and repressed endogenous retroviruses. Here the authors show that MPP8 and its association with the core HUSH complex is essential for naïve pluripotent cells; also that repression of LINE1 elements by MPP8 does not require chromatin binding, nor H3K9me3.

    • Iris Müller
    • Ann Sophie Moroni
    • Kristian Helin
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17