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Advanced filters: Author: Darja Kordic Clear advanced filters

  • The full-length structure of HUWE1 reveals the bipartite organization of a giant E3 ubiquitin ligase, comprising a catalytic HECT domain and a large, ring-shaped scaffold that provides docking sites for various substrates and regulates E3 activity.

    • Daniel B. Grabarczyk
    • Olga A. Petrova
    • Tim Clausen
    Research
    Nature Chemical Biology
    Volume: 17, P: 1084-1092