Most receptors transmit extracellular signals to the cytoplasm, but integrins can also be stimulated in the reverse direction. A recent pair of Science papers report that “inside-out” signaling from the TCR is mediated by a newly identified protein called SLAP-130 or Fyb.
- Darren G. Woodside
- Sanford J. Shattil
- Mark H. Ginsberg
