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Majority of Treponema pallidum ssp. pallidum MLST allelic profiles in the Czech Republic (2004–2022) belong to two SS14-like clusters

Eliška Vrbová
Petra Pospíšilová
David Šmajs
ResearchOpen Access29 Jul 2024
Scientific Reports

Volume: 14, P: 1-9
In vitro analysis of seven syphilis-causing Treponema pallidum strains revealed inherent growth rate differences

Juraj Bosák
Matěj Hrala
David Šmajs
ResearchOpen Access26 Sept 2025
Scientific Reports

Volume: 15, P: 1-8
Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen

Treponema pallidum, the causative agent of syphilis, is extremely well adapted to its host. In this Review, Radolf and colleagues discuss how this pathogen has streamlined its cell envelope, metabolism and genome to thrive and cause disease in humans.

Justin D. Radolf
Ranjit K. Deka
X. Frank Yang
Reviews10 Oct 2016
Nature Reviews Microbiology

Volume: 14, P: 744-759
Resistance to ceftriaxone and penicillin G among contemporary syphilis strains confirmed by natural in vitro mutagenesis

Pospíšilová and Bosák et al. provide experimental evidence that A1873G mutation in TP0705 locus leads to partial ceftriaxone and penicillin G resistance in Treponema pallidum. The majority of contemporary strains harbor this mutation and thus represent a risk of an increase in their level of resistance to β-lactam antibiotics.

Petra Pospíšilová
Juraj Bosák
David Šmajs
ResearchOpen Access10 Jun 2025
Communications Medicine

Volume: 5, P: 1-7
Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster

DNA capture and sequencing from patients with syphilis highlights the origins of a Treponema pallidum pandemic.

Natasha Arora
Verena J. Schuenemann
Homayoun C. Bagheri
Research05 Dec 2016
Nature Microbiology

Volume: 2, P: 1-6
High frequency of Nichols-like strains and increased levels of macrolide resistance in Treponema pallidum in clinical samples from Buenos Aires, Argentina

Nicolas Morando
Eliška Vrbová
María A. Pando
ResearchOpen Access29 Sept 2022
Scientific Reports

Volume: 12, P: 1-10
Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates

Idrissa S. Chuma
Christian Roos
Sascha Knauf
ResearchOpen Access02 Oct 2019
Scientific Reports

Volume: 9, P: 1-9
Colicin Z, a structurally and functionally novel colicin type that selectively kills enteroinvasive Escherichia coli and Shigella strains

Lenka Micenková
Juraj Bosák
David Šmajs
ResearchOpen Access31 Jul 2019
Scientific Reports

Volume: 9, P: 1-12
Colicin F_Y inhibits pathogenic Yersinia enterocolitica in mice

Juraj Bosák
Lenka Micenková
David Šmajs
ResearchOpen Access16 Aug 2018
Scientific Reports

Volume: 8, P: 1-12

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Majority of Treponema pallidum ssp. pallidum MLST allelic profiles in the Czech Republic (2004–2022) belong to two SS14-like clusters

In vitro analysis of seven syphilis-causing Treponema pallidum strains revealed inherent growth rate differences

Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen

Resistance to ceftriaxone and penicillin G among contemporary syphilis strains confirmed by natural in vitro mutagenesis

Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster

High frequency of Nichols-like strains and increased levels of macrolide resistance in Treponema pallidum in clinical samples from Buenos Aires, Argentina

Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates

Colicin Z, a structurally and functionally novel colicin type that selectively kills enteroinvasive Escherichia coli and Shigella strains

Colicin F_Y inhibits pathogenic Yersinia enterocolitica in mice

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