Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–8 of 8 results
Advanced filters: Author: David A. Harmin Clear advanced filters

  • Regulatory proteins bind non-coding DNA either at promoters (near to a gene's transcription start site) or at enhancers (far away). Binding at enhancers helps to bring the transcription enzyme RNA polymerase to promoters. Here, studies of some 12,000 enhancers that respond to electrical activity in neurons show that binding to enhancers also brings the polymerase to the enhancers themselves, where it transcribes a novel class of non-coding RNAs. Enhancers may thus be more similar to promoters than hitherto appreciated.

    • Tae-Kyung Kim
    • Martin Hemberg
    • Michael E. Greenberg
    Research
    Nature
    Volume: 465, P: 182-187

  • Our understanding of human brain development in health and disease is limited. The authors generated human brain organoids from stem cell-derived isolated single neural rosettes to study human cortico-striatal development and deficits caused by an autism-associated genetic abnormality in SHANK3.

    • Yueqi Wang
    • Simone Chiola
    • Aleksandr Shcheglovitov
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-25

  • A neuron-specific activity-dependent DNA repair mechanism is identified, the impairment of which may lead to neurodevelopmental disorders, neurodegeneration and ageing.

    • Elizabeth A. Pollina
    • Daniel T. Gilliam
    • Michael E. Greenberg
    ResearchOpen Access
    Nature
    Volume: 614, P: 732-741

  • Novel experiences in mice lead to opposing effects on inhibition of Fos-activated hippocampal CA1 pyramidal neurons by parvalbumin- and cholecystokinin-expressing interneurons, revealing the roles of FOS and SCG2 in neural plasticity and consolidation of memories.

    • Ee-Lynn Yap
    • Noah L. Pettit
    • Michael E. Greenberg
    Research
    Nature
    Volume: 590, P: 115-121

  • Rett syndrome is caused by mutation of the MECP2 gene that codes for a protein that binds methylated DNA; this study reveals that MeCP2 affects the expression of long genes, which often serve neuronal functions.

    • Harrison W. Gabel
    • Benyam Kinde
    • Michael E. Greenberg
    Research
    Nature
    Volume: 522, P: 89-93

  • In this study, the authors describe the subset of activity-regulated enhancers that modulate transcription in cultured neurons and that participate in the regulation of synaptic maturation. In addition, they demonstrate Fos binding to these enhancers is essential for this activity-dependent regulation of transcription.

    • Athar N Malik
    • Thomas Vierbuchen
    • Michael E Greenberg
    Research
    Nature Neuroscience
    Volume: 17, P: 1330-1339

  • Boulting et al. profile activity-dependent gene expression and regulatory elements in human induced pluripotent stem cell-derived GABAergic neurons and uncover a possible role for calcium-responsive gene promoters of these neurons in autism risk.

    • Gabriella L. Boulting
    • Ershela Durresi
    • Michael E. Greenberg
    Research
    Nature Neuroscience
    Volume: 24, P: 437-448