Nature Search

Reaction of 5-iodonaphthyl-1-nitrene with the IgE receptor on normal and tumour mast cells

David Holowka
Carlos Gitler
Henry Metzger
Research26 Feb 1981
Nature

Volume: 289, P: 806-808
Enhancing extracellular vesicle cargo loading and functional delivery by engineering protein-lipid interactions

Understanding principles that govern protein association with extracellular vesicles should expand their potential as a therapeutic modality. Here, the authors show that by localizing proteins to the plasma membrane and lipid rafts, a variety of proteins can be preferentially loaded into extracellular vesicles.

Justin A. Peruzzi
Taylor F. Gunnels
Neha P. Kamat
ResearchOpen Access04 Jul 2024
Nature Communications

Volume: 15, P: 1-18
Regulation of exocytosis and mitochondrial relocalization by Alpha-synuclein in a mammalian cell model

Meraj Ramezani
Marcus M. Wilkes
Barbara Baird
ResearchOpen Access27 Jun 2019
npj Parkinson's Disease

Volume: 5, P: 1-17
Language rhythms in baby hand movements

Hearing babies born to deaf parents babble silently with their hands.

Laura Ann Petitto
Siobhan Holowka
David Ostry
Research06 Sept 2001
Nature

Volume: 413, P: 35-36
A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis

Extracellular vesicles (EVs) contain VEGF and can contribute to tumour angiogenesis, although the mechanism remains unclear. Here, the authors find that a form of VEGF (VEGF90K) resistant to Bevacizumab but sensitive to HSP90 inhibitors, associates with EVs through its interaction with Hsp90.

Qiyu Feng
Chengliang Zhang
Richard A. Cerione
ResearchOpen Access16 Feb 2017
Nature Communications

Volume: 8, P: 1-17
Alpha synuclein modulates mitochondrial Ca²⁺ uptake from ER during cell stimulation and under stress conditions

Meraj Ramezani
Alice Wagenknecht-Wiesner
Barbara A. Baird
ResearchOpen Access23 Sept 2023
npj Parkinson's Disease

Volume: 9, P: 1-18
Non-Faradaic Electrochemical Detection of Exocytosis from Mast and Chromaffin Cells Using Floating-Gate MOS Transistors

Krishna Jayant
Amit Singhai
Edwin C. Kan
ResearchOpen Access21 Dec 2015
Scientific Reports

Volume: 5, P: 1-15
Timescale Separation of Positive and Negative Signaling Creates History-Dependent Responses to IgE Receptor Stimulation

Brooke Harmon
Lily A. Chylek
Anup K. Singh
ResearchOpen Access14 Nov 2017
Scientific Reports

Volume: 7, P: 1-14
Targeting pathological B cell receptor signalling in lymphoid malignancies

The B cell receptor (BCR) activates numerous survival and proliferation pathways, and can signal in an antigen-dependent or antigen-independent (tonic) fashion. Here, Young and Staudt discuss the signalling cascades involved, examine recent evidence for a role of BCR signalling in different subtypes of B cell lymphomas and provide an overview of pipeline candidates that target components of the BCR signalling cascade.

Ryan M. Young
Louis M. Staudt
Reviews01 Mar 2013
Nature Reviews Drug Discovery

Volume: 12, P: 229-243

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