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Showing 1–3 of 3 results
Advanced filters: Author: David Bouyssié Clear advanced filters

  • The number of publicly available proteomics datasets is growing rapidly, but a standardized approach for describing the associated metadata is lacking. Here, the authors propose a format and a software pipeline to present and validate metadata, and integrate them into ProteomeXchange repositories.

    • Chengxin Dai
    • Anja Füllgrabe
    • Yasset Perez-Riverol
    ReviewsOpen Access
    Nature Communications
    Volume: 12, P: 1-8

  • Darrigrand, Pierson et al. study the effect of mRNA splicing inhibitors on the generation of the MHC class I ligands. They developed a derivative of the spliceosome inhibitor isoginkgetin which is less toxic and more effective at enhancing antigen presentation and CD8+ T cell activation and showed greater antitumour activity in vivo. These findings identify the spliceosome as a druggable target for the development of epitope-based immunotherapies.

    • Romain Darrigrand
    • Alison Pierson
    • Sébastien Apcher
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-14