Nature Search

Crystal structure of the annexin XII hexamer and implications for bilayer insertion

Hartmut Luecke
Bryna T. Chang
Harry T. Haigler
Research30 Nov 1995
Nature

Volume: 378, P: 512-515
The Effects of Climate Change on the Phenological Interactions of Plants and Pollinators

David Inouye
ResearchOpen Access10 Aug 2009
Nature Precedings

P: 1
Climate change reduces extent of temperate drylands and intensifies drought in deep soils

Future stress on water resources, and on temperate drylands in particular, remains uncertain. Here, the authors show that climate in the late twenty first century may reduce the extent of temperate drylands, dry deep soils, and create intra-regional and intercontinental differences in ecological drought.

Daniel R. Schlaepfer
John B. Bradford
Khishigbayar Jamiyansharav
ResearchOpen Access31 Jan 2017
Nature Communications

Volume: 8, P: 1-9
Breeder turnover creates allelic variation in groups of gray wolves

David E. Ausband
ResearchOpen Access23 Sept 2025
Heredity

Volume: 134, P: 577-583
Neurofilament disguise, destruction and discipline

DAVID S. GILBERT
BARBARA J. NEWBY
BRIAN H. ANDERTON
Research14 Aug 1975
Nature

Volume: 256, P: 586-589
Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells

Igor B. Roninson
Herbert T. Abelson
Alexander Varshavsky
Research14 Jun 1984
Nature

Volume: 309, P: 626-628
A Grb2-associated docking protein in EGF- and insulin-receptor signalling

Marina Holgado-Madruga
David R. Emlet
Albert J. Wong
Research08 Feb 1996
Nature

Volume: 379, P: 560-564
Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

David D. Schlaepfer
Steven K. Hanks
Peter van der Geer
Research29 Dec 1994
Nature

Volume: 372, P: 786-791
FAK integrates growth-factor and integrin signals to promote cell migration

David J. Sieg
Christof R. Hauck
David D. Schlaepfer
Research27 Mar 2000
Nature Cell Biology

Volume: 2, P: 249-256
Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair

How adhesive forces are transduced and integrated into biochemical signals at focal adhesions (FAs) is poorly understood. Here authors show that force- FAK signaling coupling coordinates cell migration and tissue-scale forces to promote microtissue repair.

Dennis W. Zhou
Marc A. Fernández-Yagüe
Andrés J. García
ResearchOpen Access21 Apr 2021
Nature Communications

Volume: 12, P: 1-13
The role of the α4 integrin-paxillin interaction in regulating leukocyte trafficking

David M Rose
ReviewsOpen Access01 Jun 2006
Experimental & Molecular Medicine

Volume: 38, P: 191-195
Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer

The focal adhesion kinase has a role in cell adhesion and migration. In this study, a fluorescent resonance energy transfer biosensor is designed to monitor focal adhesion kinase activity at membrane microdomains, revealing that the mechanisms that activate focal adhesion kinase are stimulus dependent.

Jihye Seong
Mingxing Ouyang
Yingxiao Wang
Research26 Jul 2011
Nature Communications

Volume: 2, P: 1-9
Focal adhesion kinase: in command and control of cell motility

Satyajit K. Mitra
Daniel A. Hanson
David D. Schlaepfer
Reviews01 Jan 2005
Nature Reviews Molecular Cell Biology

Volume: 6, P: 56-68
Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer

Cancers accumulate multiple single copy number alterations, but their impact is unclear. Here, the authors computationally demonstrate a disruption of genes associated with autophagy in ovarian cancer, show impact on autophagic flux, and note the efficacy of autophagy drugs in preclinical models.

Joe Ryan Delaney
Chandni B. Patel
Dwayne G. Stupack
ResearchOpen Access15 Feb 2017
Nature Communications

Volume: 8, P: 1-11
Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

Impaired TGF-β signaling due to SMAD4 mutation in PDAC tumors initiates a STAT3-dependent signaling cascade that leads to increased stromal stiffening and disease progression.

Hanane Laklai
Yekaterina A Miroshnikova
Valerie M Weaver
Research18 Apr 2016
Nature Medicine

Volume: 22, P: 497-505
Author Correction: Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

Hanane Laklai
Yekaterina A. Miroshnikova
Valerie M. Weaver
Amendments and Corrections28 Nov 2023
Nature Medicine

Volume: 30, P: 908
Development of the Prefrontal Cortex during Adolescence: Insights into Vulnerable Neural Circuits in Schizophrenia

David A Lewis
Reviews01 Jun 1997
Neuropsychopharmacology

Volume: 16, P: 385-398
Activation of the focal adhesion kinase signal transduction pathway in cervical carcinoma cell lines and human genital epithelial cells immortalized with human papillomavirus type 18

Stephen J McCormack
Scott E Brazinski
David J Goldstein
Research17 Jul 1997
Oncogene

Volume: 15, P: 265-274
PET Measures of Amphetamine-Induced Dopamine Release in Ventral versus Dorsal Striatum

Wayne C Drevets
Julie C Price
Chester Mathis
Research01 Dec 1999
Neuropsychopharmacology

Volume: 21, P: 694-709
FAK in cancer: mechanistic findings and clinical applications

Focal adhesion kinase (FAK) can promote tumour growth and metastasis through various kinase-dependent and kinase-independent pathways. This Review discusses the roles of FAK in tumour cells and cells of the microenvironment, as well as the progress that is being made in the clinical development of FAK inhibitors.

Florian J. Sulzmaier
Christine Jean
David D. Schlaepfer
Reviews07 Aug 2014
Nature Reviews Cancer

Volume: 14, P: 598-610
Apoptotic cues from the extracellular matrix: regulators of angiogenesis

Dwayne G Stupack
David A Cheresh
Reviews08 Dec 2003
Oncogene

Volume: 22, P: 9022-9029
Anatomical MRI Study of Subgenual Prefrontal Cortex in Bipolar and Unipolar Subjects

Paolo Brambilla
Mark A Nicoletti
Jair C Soares
Research18 Apr 2002
Neuropsychopharmacology

Volume: 27, P: 792-799
Requirement for focal adhesion kinase in tumor cell adhesion

Kavita Maung
David J Easty
Dorothy C Bennett
Research19 Nov 1999
Oncogene

Volume: 18, P: 6824-6828
A role for VEGF as a negative regulator of pericyte function and vessel maturation

VEGF is an important angiogenic factor that has been implicated in tumourigenesis. Two papers now show that the function of VEGF is far more complex, as VEGF can negatively regulate angiogenesis and limit tumourigenesis. This study found that VEGF can inhibit angiogenesis by impeding the function of the PDGF receptor on pericytes, leading to a loss of pericyte coverage of blood vessels. This involves the formation of heterodimers between the receptors for VEGF and PDGF.

Joshua I. Greenberg
David J. Shields
David A. Cheresh
Research09 Nov 2008
Nature

Volume: 456, P: 809-813
Targeting FAK in anticancer combination therapies

Focal adhesion kinase (FAK) is overexpressed in many cancers and is involved in a multitude of oncogenic processes and resistance mechanisms. This Review discusses the rationale and preclinical evidence for FAK-based combination therapies and strategies for future development.

John C. Dawson
Alan Serrels
Margaret C. Frame
Reviews17 Mar 2021
Nature Reviews Cancer

Volume: 21, P: 313-324
TGFBI remodels adipose metabolism by regulating the Notch-1 signaling pathway

Seul Gi Lee
Jongbeom Chae
Ju-Ock Nam
ResearchOpen Access01 Mar 2023
Experimental & Molecular Medicine

Volume: 55, P: 520-531
Endothelial angiogenic activity and adipose angiogenesis is controlled by extracellular matrix protein TGFBI

Seul Gi Lee
Jin Soo Kim
Ju-Ock Nam
ResearchOpen Access06 May 2021
Scientific Reports

Volume: 11, P: 1-11
Rgnef promotes ovarian tumor progression and confers protection from oxidative stress

Elizabeth G. Kleinschmidt
Nichol L. G. Miller
David D. Schlaepfer
Research15 Jul 2019
Oncogene

Volume: 38, P: 6323-6337
Ventral Striatal Dopamine Release in Response to Smoking a Regular vs a Denicotinized Cigarette

Arthur L Brody
Mark A Mandelkern
Edythe D London
Research18 Jun 2008
Neuropsychopharmacology

Volume: 34, P: 282-289
KLF8 promotes human breast cancer cell invasion and metastasis by transcriptional activation of MMP9

X Wang
H Lu
J Zhao
ResearchOpen Access13 Dec 2010
Oncogene

Volume: 30, P: 1901-1911
Deep brain stimulation for refractory obsessive-compulsive disorder (OCD): emerging or established therapy?

Hemmings Wu
Marwan Hariz
Bart Nuttin
ReviewsOpen Access03 Nov 2020
Molecular Psychiatry

Volume: 26, P: 60-65

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