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Showing 1–3 of 3 results
Advanced filters: Author: David Fiflis Clear advanced filters

  • Formation of biomolecular condensates composed of proteins and RNA facilitates the regulation of gene expression by modulating translation or facilitating RNA processing. Now, synthetic ribonucleoprotein granules created with engineered intrinsically disordered proteins selectively sequester mRNA and enhance protein translation in cells. These highly liquid-like condensates exchange biomolecules across the cell and facilitate target mRNA and ribosome partitioning.

    • Daniel Mark Shapiro
    • Sonal Deshpande
    • Ashutosh Chilkoti
    Research
    Nature Chemistry
    Volume: 17, P: 448-456

  • The ability to edit large stretches of mRNA transcripts remains a significant challenge. Here, the authors demonstrate that CRISPR-Cas13 systems can be repurposed to assist trans-splicing of exogenous RNA fragments into an endogenous pre-mRNA transcript, a method termed CRISPR Assisted mRNA Fragment Trans-splicing (CRAFT).

    • David N. Fiflis
    • Nicolas A. Rey
    • Aravind Asokan
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14