Nature Search

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

Philip De Jager and colleagues report results of a large genome-wide association and replication study for multiple sclerosis. The work uncovers three new susceptibility loci for MS, including common and rare variants at TNFRSF1A and common variants at IRF8 and CD6.

Philip L De Jager
Xiaoming Jia
Jorge R Oksenberg
Research14 Jun 2009
Nature Genetics

Volume: 41, P: 776-782
A network analysis of carbapenem-resistant Klebsiella pneumoniae among healthcare facilities

Courtney L. Luterbach
Dana K. Pasquale
David Roach
ResearchOpen Access29 Jul 2025
Scientific Reports

Volume: 15, P: 1-11
Suppressing quantum errors by scaling a surface code logical qubit

A study demonstrating increasing error suppression with larger surface code logical qubits, implemented on a superconducting quantum processor.

Rajeev Acharya
Igor Aleiner
Ningfeng Zhu
ResearchOpen Access22 Feb 2023
Nature

Volume: 614, P: 676-681
The peri-germ cell membrane: poorly characterized but key interface for plant reproduction

Naoya Sugi
Andrea R. M. Calhau
Thomas Widiez
Correspondence15 Oct 2024
Nature Plants

Volume: 10, P: 1607-1609
Waves of endemic foot-and-mouth disease in eastern Africa suggest feasibility of proactive vaccination approaches

A study of foot-and-mouth disease in Tanzanian livestock and buffalo populations identifies waves spreading through cattle herds across the region, and economic impacts to rural communities that could be alleviated by targeted vaccination.

Miriam Casey-Bryars
Richard Reeve
Tiziana Lembo
Research06 Aug 2018
Nature Ecology & Evolution

Volume: 2, P: 1449-1457
Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma

Clinical testing of BCR inhibition on DLBCL reveals determinants of response.

Wyndham H Wilson
Ryan M Young
Louis M Staudt
Research20 Jul 2015
Nature Medicine

Volume: 21, P: 922-926
Mutations in MTHFR and POLG impaired activity of the mitochondrial respiratory chain in 46-year-old twins with spastic paraparesis

Arnaud Wiedemann
Céline Chery
Abderrahim Oussalah
Research23 Oct 2019
Journal of Human Genetics

Volume: 65, P: 91-98
Exponential suppression of bit or phase errors with cyclic error correction

Repetition codes running many cycles of quantum error correction achieve exponential suppression of errors with increasing numbers of qubits.

Zijun Chen
Kevin J. Satzinger
Julian Kelly
ResearchOpen Access14 Jul 2021
Nature

Volume: 595, P: 383-387
Heavy-duty truck electrification and the impacts of depot charging on electricity distribution systems

Increasing attention is being paid to the electrification of trucks, in particular for short-haul operations. Borlaug et al. simulate depot charging load profiles based on real-world operating schedules to explore future charging requirements and assess the likely distribution substation upgrades needed to support them.

Brennan Borlaug
Matteo Muratori
Charlie McQueen
Research21 Jun 2021
Nature Energy

Volume: 6, P: 673-682
Molecular analysis of spontaneous somatic mutants

Kayode Adetugbo
César Milstein
David S. Secher
Reviews27 Jan 1977
Nature

Volume: 265, P: 299-304
Antineutrino astronomy and geophysics

Lawrence M. Krauss
Sheldon L. Glashow
David N. Schramm
Reviews19 Jul 1984
Nature

Volume: 310, P: 191-198
The common marmoset genome provides insight into primate biology and evolution

Kim Worley and colleagues report the whole-genome sequence of the common marmoset, Callithrix jacchus, the first New World monkey to be sequenced.

Kim C Worley
Wesley C Warren
Richard K Wilson
ResearchOpen Access20 Jul 2014
Nature Genetics

Volume: 46, P: 850-857
Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

Sofia Papadia
Francesc X Soriano
Giles E Hardingham
Research23 Mar 2008
Nature Neuroscience

Volume: 11, P: 476-487
Publisher Correction: Signatures of TOP1 transcription-associated mutagenesis in cancer and germline

Martin A. M. Reijns
David A. Parry
Andrew P. Jackson
Amendments and CorrectionsOpen Access03 May 2022
Nature

Volume: 605, P: E7
Author Correction: A consensus protocol for functional connectivity analysis in the rat brain

Joanes Grandjean
Gabriel Desrosiers-Gregoire
Andreas Hess
Amendments and Corrections18 Apr 2023
Nature Neuroscience

Volume: 26, P: 1127-1128
The secret life of Pickering emulsions: particle exchange revealed using two colours of particle

David J. French
Aidan T. Brown
Paul S. Clegg
ResearchOpen Access10 Aug 2016
Scientific Reports

Volume: 6, P: 1-9
A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes

Lynsey M Cree
David C Samuels
Patrick F Chinnery
Research27 Jan 2008
Nature Genetics

Volume: 40, P: 249-254
Therapeutic antibody targeting of individual Notch receptors

The four receptors of the Notch family are transmembrane proteins through which mammalian cells communicate to regulate cell fate and growth. Aberrant signalling through each receptor has been linked to disease, so the Notch pathway is a compelling drug target. But current drugs cannot distinguish between the different Notch proteins. Here, phage display technology has been used to generate highly specialized antibodies, enabling the functions of Notch1 and Notch2 to be discriminated in humans and mice.

Yan Wu
Carol Cain-Hom
Christian W. Siebel
Research15 Apr 2010
Nature

Volume: 464, P: 1052-1057
Author Correction: T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

Katie J. Ewer
Jordan R. Barrett
Elizabeth Stafford
Amendments and Corrections21 May 2021
Nature Medicine

Volume: 27, P: 1116
Enhanced performance in fusion plasmas through turbulence suppression by megaelectronvolt ions

Experiments at the Joint European Torus tokamak show improved thermal ion confinement in the presence of highly energetic ions and Alfvénic instabilities in the plasma.

S. Mazzi
J. Garcia
I. Zychor
Research30 Jun 2022
Nature Physics

Volume: 18, P: 776-782
Calibrating the zenith of dinosaur diversity in the Campanian of the Western Interior Basin by CA-ID-TIMS U–Pb geochronology

Jahandar Ramezani
Tegan L. Beveridge
Eric M. Roberts
ResearchOpen Access26 Sept 2022
Scientific Reports

Volume: 12, P: 1-20
Striatal microRNA controls cocaine intake through CREB signalling

Extended cocaine taking triggers several structural and functional changes in the brain that may lead to compulsive drug seeking, but the mechanisms that regulate the process are unclear. Here, a microRNA — miR-212 — is identified that is upregulated in the striatum of rats with a history of extended access to cocaine. The authors suggest that miR-212 protects against the development of compulsive drug taking, and that it may act through the CREB protein, a known regulator of the rewarding effects of cocaine.

Jonathan A. Hollander
Heh-In Im
Paul J. Kenny
Research08 Jul 2010
Nature

Volume: 466, P: 197-202
Insights for precision oncology from the integration of genomic and clinical data of 13,880 tumors from the 100,000 Genomes Cancer Programme

The first report from the Cancer Programme of the 100,000 Genomes Project presents whole-genome sequencing profiles of 13,880 solid tumors spanning 33 cancer types, combined with real-world clinical data, providing insights for precision oncology.

Alona Sosinsky
John Ambrose
Nirupa Murugaesu
ResearchOpen Access11 Jan 2024
Nature Medicine

Volume: 30, P: 279-289
Trends in extreme rainfall over the past 55 years suggest springtime subhourly rainfall extremes have intensified in Mahantango Creek, Pennsylvania

Anthony R. Buda
David J. Millar
Adrian R.H. Wiegman
ResearchOpen Access13 Nov 2024
Scientific Reports

Volume: 14, P: 1-19
Role of lymphadenectomy in the staging of endometrial cancer

Pelvic lymphadenectomy offers no therapeutic benefit to women diagnosed with early-stage endometrial cancer according to a new study. Lymphadenectomy can only be recommended as part of a clinical trial in this disease setting; however, it can offer valuable staging information in those with advanced disease.

Kimberly E. Resnick
David E. Cohn
Jeffrey M. Fowler
News & Views01 Jul 2009
Nature Reviews Clinical Oncology

Volume: 6, P: 382-384
Lightning in astronomy

The author suggests that evidence for lightning on a grand scale in astronomy is most convincing. It might explain stellar flares, cosmic jets, quasars, galactic evolution, and much more. In this model, electrical charges accumulate in apparently highly conducting atmospheres.

E. W. Crew
News & Views13 Dec 1974
Nature

Volume: 252, P: 539-542
Negotiating Nile infrastructure management should consider climate change uncertainties

High uncertainty exists in the projected climate change impacts on the Nile’s economies and water-dependent sectors. Under these uncertainties, managing the Grand Ethiopian Renaissance Dam cooperatively and adaptively can produce economic and water management benefits for Ethiopia, Sudan and Egypt.

Mohammed Basheer
Victor Nechifor
Julien J. Harou
News & Views09 Jan 2023
Nature Climate Change

Volume: 13, P: 17-19
Deciphering the impact of genomic variation on function

The Impact of Genomic Variation on Function Consortium is combining single-cell mapping, genomic perturbations and predictive modelling to investigate relationships between human genomic variation, genome function and phenotypes and will provide an open resource to the community.

Jesse M. Engreitz
Heather A. Lawson
Ella K. Samer
Reviews04 Sept 2024
Nature

Volume: 633, P: 47-57
T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

A single dose of the ChAdOx1 nCoV-19 vaccine elicits antibodies and cytokine-producing T cells that might help control or prevent SARS-CoV-2 infection.

Katie J. Ewer
Jordan R. Barrett
Elizabeth Stafford
Research17 Dec 2020
Nature Medicine

Volume: 27, P: 270-278
Seafloor deformation and forecasts of the April 2011 eruption at Axial Seamount

The Axial Seamount submarine volcano exhibits an inflation–deflation cycle comparable to similar volcanoes on land. Measurements of ocean bottom pressure document the entire inflation–deflation cycle between eruptions at Axial Seamount in 1998 and 2011, and imply that the timing of submarine eruptions could be more predictable than that of their subaerial counterparts.

William W. Chadwick Jr
Scott L. Nooner
Marvin D. Lilley
Research10 Jun 2012
Nature Geoscience

Volume: 5, P: 474-477
Gene expression studies of a human monocyte cell line identify dissimilarities between differently manufactured glatiramoids

Sarah Kolitz
Tal Hasson
Iris Grossman
ResearchOpen Access22 May 2015
Scientific Reports

Volume: 5, P: 1-14
Relative sea-level rise around East Antarctica during Oligocene glaciation

The growth of ice on Antarctica about 34 million years ago affected sea level. A combination of modelling and marine sediment analyses shows that sea level near the developing ice sheet first fell and then rose as a result of crustal deformation imposed by the ice growth.

Paolo Stocchi
Carlota Escutia
Masako Yamane
Research21 Apr 2013
Nature Geoscience

Volume: 6, P: 380-384
ALTERED VENTRICULAR FUNCTION DURING SEPTAL AND RIGHT VENTRICULAR ISCHEMIA IN ANESTHETIZED DOGS

David E Fixler
George A Monroe
Mickey Wheeler
Research01 Apr 1974
Pediatric Research

Volume: 8, P: 349
A NEW NON-INVASIVE TECHNIQUE FOR THE LOCALIZATION OF THE SITE OF LEFT VENTRICULAR OUTFLOW TRACT OBSTRUCTION (LVOTO)

David J Sahn
William F Friedman
Research01 Apr 1974
Pediatric Research

Volume: 8, P: 354
Comparative genomic analysis of three Leishmania species that cause diverse human disease

Christopher S Peacock
Kathy Seeger
Matthew Berriman
Research17 Jun 2007
Nature Genetics

Volume: 39, P: 839-847
Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing

To increase the affinity of designed protein inhibitors for influenza hemagglutinin, Whitehead et al. use yeast display and deep sequencing to measure the effects on binding of ~1,000 amino-acid substitutions. Rare beneficial mutations are then combined and screened, yielding inhibitors with ~25-fold lower dissociation constants.

Timothy A Whitehead
Aaron Chevalier
David Baker
Research27 May 2012
Nature Biotechnology

Volume: 30, P: 543-548
INDUCTION OF KIDNEY HEME OXYGENASE BY INDIUM, GALLIUM, AND ARSENIC.431

Ryokei K Imai
Hendrik J Vreman
Kathleen S Squibb
Research01 Apr 1996
Pediatric Research

Volume: 39, P: 74
New filovirus disease classification and nomenclature

The recent large outbreak of Ebola virus disease (EVD) in Western Africa resulted in greatly increased accumulation of human genotypic, phenotypic and clinical data, and improved our understanding of the spectrum of clinical manifestations. As a result, the WHO disease classification of EVD underwent major revision.

Jens H. Kuhn
Takuya Adachi
Zabulon Yoti
Comments & Opinion29 Mar 2019
Nature Reviews Microbiology

Volume: 17, P: 261-263
Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk

Richard Houlston and colleagues identify common variants at four loci associated with risk of chronic lymphocytic leukemia, including a coding variant in FARP2 on 2q37.3 and a noncoding variant in the region upstream of MYC on 8q24.21.

Dalemari Crowther-Swanepoel
Peter Broderick
Richard S Houlston
Research10 Jan 2010
Nature Genetics

Volume: 42, P: 132-136
A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility

David Reich
Nick Patterson
David A Hafler
Research25 Sept 2005
Nature Genetics

Volume: 37, P: 1113-1118
Author Correction: Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease

James M. Roe
Didac Vidal-Piñeiro
Michael Vacher
Amendments and CorrectionsOpen Access07 Feb 2022
Nature Communications

Volume: 13, P: 1
Author Correction: High-depth African genomes inform human migration and health

Ananyo Choudhury
Shaun Aron
Neil A. Hanchard
Amendments and CorrectionsOpen Access12 Apr 2021
Nature

Volume: 592, P: E26
Author Correction: Comparative and demographic analysis of orang-utan genomes

Devin P. Locke
LaDeana W. Hillier
Richard K. Wilson
Amendments and CorrectionsOpen Access12 Aug 2022
Nature

Volume: 608, P: E36
Author Correction: Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses

Jordan R. Barrett
Sandra Belij-Rammerstorfer
Dalila Zizi
Amendments and Corrections06 May 2021
Nature Medicine

Volume: 27, P: 1113
Maturation of Eupneic Respiration in the Neonatal Monkey

William A LaFramboise
Richard E Tuck
Robert D Guthrie
Research01 Oct 1984
Pediatric Research

Volume: 18, P: 943-948
Osteogenesis Imperfecta: Morphologic and Biochemical Studies of Connective Tissue

Fenwick C Riley
Jenifer Jowsey
David M Brown
Research01 Sept 1973
Pediatric Research

Volume: 7, P: 757-768
Impairments of Reversal Learning and Response Perseveration after Repeated, Intermittent Cocaine Administrations to Monkeys

J David Jentsch
Peter Olausson
Jane R Taylor
Research02 Aug 2001
Neuropsychopharmacology

Volume: 26, P: 183-190
Publisher Correction: Reporting guideline for the early-stage clinical evaluation of decision support systems driven by artificial intelligence: DECIDE-AI

Baptiste Vasey
Myura Nagendran
Zane B. Perkins
Amendments and Corrections12 Aug 2022
Nature Medicine

Volume: 28, P: 2218
Author Correction: Supporting US public health experts

Ron Cohen
Cedric Francois
Sandy Zweifach
Amendments and Corrections17 Dec 2020
Nature Biotechnology

Volume: 39, P: 115
Comparative and demographic analysis of orang-utan genomes

The genome of the southeast Asian orang-utan has been sequenced. The draft assembly of a Sumatran individual alongside sequence data from five Sumatran and five Bornean orang-utan genomes is presented. The resources and analyses described offer new opportunities in evolutionary genomics, insights into hominid biology, and an extensive database of variation for conservation efforts.

Devin P. Locke
LaDeana W. Hillier
Richard K. Wilson
ResearchOpen Access26 Jan 2011
Nature

Volume: 469, P: 529-533

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