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Showing 1–6 of 6 results

Advanced filters: Author: David G. Hulcoop Clear advanced filters

Temporal trends in evidence supporting novel drug target discovery

Here the authors implement a comprehensive timestamping across millions of pieces of biomedical evidence supporting target–disease associations in the Open Targets Platform and analyse trends in evidence supporting novel drug target discovery over the last two decades.

Maria J. Falaguera
Ellen M. McDonagh
Ian Dunham
ResearchOpen Access07 Dec 2025
Nature Communications

Volume: 17, P: 1-9
Archetypes of Open Science Partnerships: connecting aims and means in open biomedical research collaborations

Maria Theresa Norn
Laia Pujol Priego
Susanne Müller
ResearchOpen Access11 Sept 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-11
Human genetics evidence supports two-thirds of the 2021 FDA-approved drugs

David Ochoa
Mohd Karim
Ian Dunham
News08 Jul 2022
Nature Reviews Drug Discovery

Volume: 21, P: 551
Open Targets: 10 years of partnership in target discovery

The Open Targets consortium was founded in 2014 to translate insights from genetics and functional genomics into identifying and prioritizing therapeutic targets. We highlight key achievements and insights stemming from this partnership of academic and industry scientists.

David G. Hulcoop
Gosia Trynka
Ellen M. McDonagh
Comments & Opinion17 Dec 2024
Nature Reviews Drug Discovery

Volume: 24, P: 153-154
A data science roadmap for open science organizations engaged in early-stage drug discovery

Artificial intelligence is greatly accelerating research in drug discovery, but its development is still hindered by the lack of available data. Here the authors present data management and data science recommendations to help reach AI’s potential in the field.

Kristina Edfeldt
Aled M. Edwards
Matthieu Schapira
ReviewsOpen Access05 Jul 2024
Nature Communications

Volume: 15, P: 1-10
An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci

Open Targets Genetics is a community resource that provides systematic fine mapping at human GWAS loci, enabling users to prioritize genes at disease-associated regions and assess their potential as drug targets.

Edward Mountjoy
Ellen M. Schmidt
Maya Ghoussaini
Research28 Oct 2021
Nature Genetics

Volume: 53, P: 1527-1533