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Showing 1–8 of 8 results

Advanced filters: Author: David Hollenstein Clear advanced filters

Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy

Licheva, Pflaum, Babic, Mancilla et al. show that low-affinity cargo–receptor interactions promote autophagy receptor mobility and condensation of the scaffold protein Atg11 to trigger initiation hub and phagophore formation.

Mariya Licheva
Jeremy Pflaum
Claudine Kraft
ResearchOpen Access07 Jan 2025
Nature Cell Biology

Volume: 27, P: 283-297
Author Correction: Structural prediction of protein models using distance restraints derived from cross-linking mass spectrometry data

Zsuzsanna Orbán-Németh
Rebecca Beveridge
Karl Mechtler
Amendments and Corrections25 Jun 2018
Nature Protocols

Volume: 13, P: 1724
Spatial control of avidity regulates initiation and progression of selective autophagy

The molecular principles governing the initiation of autophagosome formation are not clearly understood. Here we show that the vacuolar protein Vac8 coordinates this process by promoting an avidity-driven assembly of several autophagy factors.

David M. Hollenstein
Mariya Licheva
Claudine Kraft
ResearchOpen Access10 Dec 2021
Nature Communications

Volume: 12, P: 1-18
Atg4 proteolytic activity can be inhibited by Atg1 phosphorylation

The protease Atg4 mediates Atg8 lipidation, required for autophagosome biogenesis, but also triggers Atg8 release from the membranes, however is unclear how these steps are coordinated. Here the authors show that phosphorylation by Atg1 inhibits Atg4 at autophagosome formation sites.

Jana Sánchez-Wandelmer
Franziska Kriegenburg
Fulvio Reggiori
ResearchOpen Access18 Aug 2017
Nature Communications

Volume: 8, P: 1-10
Reply to ‘Defining distance restraints in HADDOCK’

Zsuzsanna Orbán-Németh
Rebecca Beveridge
Karl Mechtler
Correspondence25 Jun 2018
Nature Protocols

Volume: 13, P: 1503-1505
Germline deletion of the miR-17∼92 cluster causes skeletal and growth defects in humans

Andrea Ventura and colleagues report germline hemizygous deletions in the miR-17~92 cluster in individuals with features overlapping Feingold syndrome. Mice with targeted deletions in miR17~92 also display growth and skeletal defects.

Loïc de Pontual
Evelyn Yao
Jeanne Amiel
Research04 Sept 2011
Nature Genetics

Volume: 43, P: 1026-1030
Structural prediction of protein models using distance restraints derived from cross-linking mass spectrometry data

This protocol describes how to use distance restraints obtained from cross-linking mass spectrometry (XL-MS) experiments to guide the structural prediction of proteins and protein complexes.

Zsuzsanna Orbán-Németh
Rebecca Beveridge
Karl Mechtler
Protocols08 Feb 2018
Nature Protocols

Volume: 13, P: 478-494
Long-term monitoring of patients with infantile-onset Pompe disease on enzyme replacement therapy using a urinary glucose tetrasaccharide biomarker

Sarah P Young
Haoyue Zhang
David S Millington
Research10 Jun 2009
Genetics in Medicine

Volume: 11, P: 536-541