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Building C(sp³)-rich complexity by combining cycloaddition and C–C cross-coupling reactions

Combining cycloaddition and carbon–carbon cross-coupling offers a way of simplifying the enantioselective preparation of chemical building blocks, natural products and medicines such as the antipsychotic asenapine.

Tie–Gen Chen
Lisa M. Barton
Phil S. Baran
Research30 Jul 2018
Nature

Volume: 560, P: 350-354

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Building C(sp3)-rich complexity by combining cycloaddition and C–C cross-coupling reactions

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Building C(sp³)-rich complexity by combining cycloaddition and C–C cross-coupling reactions