Blue copper proteins serve as models for understanding how proteins tune metal binding properties, however, the mechanism through which they do so remains unclear. Here, the authors investigate carbon-deuterium bond vibrations in Nostocplastocyanin to study key copper-ligand interactions in different redox states, and reveal specific impacts of perturbation to the cupredoxin scaffold on copper coordination and the redox properties of plastocyanin.
- Claire C. Mammoser
- Brynn E. LeMasters
- Megan C. Thielges
