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Homeostatic scaling ensures behavioural stability during corticosterone negative feedback

Neilen Rasiah
Tamás Füzesi
Jaideep S. Bains
ResearchOpen Access24 Dec 2025
Molecular Psychiatry

P: 1-14
Hypothalamic CRH neurons represent physiological memory of positive and negative experience

How physiological memories are encoded is not fully understood. Here the authors show how physiological memories of aversive and appetitive experience are represented by corticotropin-releasing hormone synthesizing neurons in the paraventricular nucleus of the hypothalamus and demonstrate that behavioral readouts may not accurately reflect physiological changes invoked by the memory of salient experiences.

Tamás Füzesi
Neilen P. Rasiah
Jaideep S. Bains
ResearchOpen Access21 Dec 2023
Nature Communications

Volume: 14, P: 1-12
Paraventricular nucleus CRH neurons encode stress controllability and regulate defensive behavior selection

Prior stressful experience affects subsequent behavior even in different situations. Daviu et al. demonstrate that CRH^PVN neurons encode stress controllability and contribute to shifts between active and passive innate defensive strategies.

Núria Daviu
Tamás Füzesi
Jaideep S. Bains
Research17 Feb 2020
Nature Neuroscience

Volume: 23, P: 398-410
Social transmission and buffering of synaptic changes after stress

In mice, stress-induced priming of glutamate synapses in the PVN can be transmitted through social interactions. This requires PVN CRH neuron activation in both of the interacting mice and release of an alarm pheromone from the stressed mouse.

Toni-Lee Sterley
Dinara Baimoukhametova
Jaideep S. Bains
Research08 Jan 2018
Nature Neuroscience

Volume: 21, P: 393-403
Astrocytes amplify neurovascular coupling to sustained activation of neocortex in awake mice

Neuronal activity increases local cerebral blood flow (CBF) to satisfy metabolic demand, yet the role of astrocytes in this phenomenon is controversial. Here, the authors show that astrocytes amplify CBF only when neuronal activity is sustained.

Adam Institoris
Milène Vandal
Grant R. Gordon
ResearchOpen Access22 Dec 2022
Nature Communications

Volume: 13, P: 1-17

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Homeostatic scaling ensures behavioural stability during corticosterone negative feedback

Hypothalamic CRH neurons represent physiological memory of positive and negative experience

Paraventricular nucleus CRH neurons encode stress controllability and regulate defensive behavior selection

Social transmission and buffering of synaptic changes after stress

Astrocytes amplify neurovascular coupling to sustained activation of neocortex in awake mice

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