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Showing 1–15 of 15 results
Advanced filters: Author: David S. Rickman Clear advanced filters

  • The transition of androgen receptor-dependent prostate cancer to a therapy resistant cancer with neuroendocrine phenotype is an important process that remains poorly understood. Here, the authors show that PKCλ/ι-loss promotes epigenetic reprogramming resulting in a TGFβ resistance programme via transcriptional upregulation of translational machinery.

    • Shankha S. Chatterjee
    • Juan F. Linares
    • Maria T. Diaz-Meco
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-23

  • The components of the tumour microenvironment contribute to prostate cancer initiation and progression. Here the authors perform single-cell RNA sequencing and spatial transcriptomics analysis of prostate cancer stroma from mouse models at different stages of the disease and develop a gene signature to predict distant metastasis in patients.

    • Hubert Pakula
    • Mohamed Omar
    • Massimo Loda
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21

  • Metastatic castration-resistant prostate cancer is treated with the microtubule-stabilizing drugs taxanes, but resistance ultimately develops. Here Galletti et al.show that ERG, a transcription factor commonly overexpressed in prostate cancers, confers taxane resistance by binding to soluble tubulin.

    • Giuseppe Galletti
    • Alexandre Matov
    • David S. Rickman
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-12

  • Pineoblastoma is a rare pediatric cancer. Here, the authors present inactivation of Rb plus p53 via a WAP-Cre transgene induces metastatic pineoblastoma resembling human disease, and using this model, predict tricyclic antidepressants as a potential therapy for pineoblastoma, supported by their pre-clinical model.

    • Philip E. D. Chung
    • Deena M. A. Gendoo
    • Eldad Zacksenhaus
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-19

  • Silicon photonics and devices based on group IV elements are overcoming the tough economic downturns that have rocked industry over the past 12 years. Cross fertilization between academia and industry may lead to new devices that are both innovative and profitable.

    • David Pile
    News & Views
    Nature Photonics
    Volume: 6, P: 807-808

  • Enhancer of zeste homolog 2 (EZH2) has been implicated as a driver of disease progression and resistance to hormonal therapies. Here, the authors focus on EZH2 in two subtypes of advanced prostate cancer and report how it modulates the bivalent genes thereby leading to forward differentiation after being targeted in neuroendocrine prostate cancer.

    • Varadha Balaji Venkadakrishnan
    • Adam G. Presser
    • Himisha Beltran
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • The heterogeneity of tumor evolution from AR-positive, adenocarcinoma to AR-negative, neuroendocrine prostate cancer (NEPC) is not fully characterized. Here the authors generate a mouse model to show that Rb1 loss and MYCN overexpression accelerates the progression to AR-negative NEPC and identify emergence of distinct subpopulations of NEPC cells.

    • Nicholas J. Brady
    • Alyssa M. Bagadion
    • David S. Rickman
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Although resistance develops in response to androgen receptor-targeted therapy in advanced prostate cancer, the underlying mechanisms remain unclear. The protein ZMYND8 is now shown to bind FOXM1 and the SWI–SNF complex, promoting the onset of neuroendocrine prostate cancer, which can thus be abrogated through small-molecule ZMYND8 inhibition.

    • Kate E. Dunmore
    • David S. Rickman
    News & Views
    Nature Cancer
    Volume: 6, P: 564-566

  • No effective therapies exist for dry age-related macular degeneration. In this perspective, the authors propose that research should emphasize system biology approaches that integrate various ‘omics’ data into mathematical models to establish pathogenic mechanisms on which to design novel treatments, and identify biomarkers that predict disease progression and therapeutic response.

    • James T. Handa
    • Cathy Bowes Rickman
    • Lindsay A. Farrer
    ReviewsOpen Access
    Nature Communications
    Volume: 10, P: 1-11