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Showing 1–8 of 8 results
Advanced filters: Author: David Sarlah Clear advanced filters

  • Synthetic routes to aminoglycosides are often long and rely upon the coupling of semisynthetically produced fragments. Now, an enantioselective, copper-catalysed hydroamination of benzene has been developed to enable access to the aminoglycoside antibiotic ribostamycin. This bottom-up strategy provides modular and expedient entry into the aminocyclitol class.

    • Chad N. Ungarean
    • Petra Galer
    • David Sarlah
    Research
    Nature Synthesis
    Volume: 1, P: 542-547

  • Nanographenes and polycyclic aromatic hydrocarbons (PAHs) are important classes of compounds with numerous applications, but challenging to access due to a lack of programmable and diversity-oriented methods. Here, the authors report a diversity-oriented, growth-from-template synthesis of nanographenes enabled by iterative annulative π-extension reactions from small PAH starting materials.

    • Wataru Matsuoka
    • Hideto Ito
    • Kenichiro Itami
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9

  • Enantioselective hydrogenation is a stalwart reaction in synthetic chemistry. Now, hydrogenation of tetrasubstituted 1,2-dihydronaphthalene esters gives access to more than 30 cyclolignan natural products.

    • David B. Ryffel
    • David Sarlah
    News & Views
    Nature Synthesis
    Volume: 3, P: 937-938

  • Alkenyl halides are some of the most useful building blocks for synthesizing small organic molecules. A catalyst has now allowed their direct preparation from widely available alkenes using the cross-metathesis reaction. See Article p.459

    • David Sarlah
    News & Views
    Nature
    Volume: 531, P: 453-454

  • Dearomatization reactions that can simultaneously introduce functionality are valuable transformations that are largely underdeveloped. Now, a synthetic strategy based on the combination of arenophiles with catalytic dihydroxylation reactions enables rapid and controlled access to synthetically useful cyclohexene and cyclohexadiene derivatives from readily available arene starting materials.

    • Emma H. Southgate
    • Jola Pospech
    • David Sarlah
    Research
    Nature Chemistry
    Volume: 8, P: 922-928

  • RiPP discovery has expanded the scope of post-translational modification chemistry, but genome mining of RiPP classes remains an unsolved challenge. Here, the authors employed bioinformatics and synthetic biology approaches to discover and characterize an unknown class of RiPPs, defined by an unusual amino-modified C-terminus.

    • Hengqian Ren
    • Shravan R. Dommaraju
    • Huimin Zhao
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13