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A full understanding of the heating and dynamics of the Sun's atmosphere remains elusive, but magnetohydrodynamic waves are believed to be crucial. Using observations from the ROSA imager, this study finds compressive waves in the solar chromosphere, which may provide the energy needed for coronal heating.

Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.

Dissociative reactions in the solid state are prone to sample damage. Now, improved sample handling and measurement conditions enable the study of the dissociative reaction of a model triatomic system in the solid state on ultrafast timescales, revealing the significant impact of lattice coordination on the reaction pathway.

Excited conformation state of biomolecule is transient and high-energy conformation state. Here the authors use NMR spectroscopy and computational modeling to reveal the 3D structure of HIV-1 TAR RNA excited conformational state.

FacZ is a division site placement factor that antagonizes the cell division protein GpsB in Staphylococcus aureus.

Malaria parasites from patients who fail atovaquone therapies are highly drug-resistant, with mutations at Y268 in cytochrome b. Here the authors show that this mutation results in multiple defects in the parasite’s development and prevents transmission from mosquitoes to mice.

Tisza et al. carry out a sequencing-based analysis of wastewater samples from major cities, to detect and quantify hundreds of distinct pathogenic viruses, finding striking correlations between virus abundance and local clinical cases.

msTrawler improves quantitative analysis of multiplexed mass spectrometry proteomics data when combining isobaric data across multiple batches.

A biochemical and structural analysis demonstrates that alterations at the substrate-binding pocket of the main protease of SARS-CoV-2 can allow the virus to develop resistance to nirmatrelvir in two distinct ways.

Electron spin in quantum dots are extensively studied as a qubit for quantum information processing. However, the coherence of electron spin is deleteriously influenced by nuclear spin. Quantum-dot holes are a potential alternative. Full control over hole-spin qubits is now achieved using picosecond lasers.

Panos Deloukas, Nilesh Samani and colleagues report a large-scale association analysis using the Metabochip array in 63,746 coronary artery disease cases and 130,681 controls. They identify 15 susceptibility loci, refine previous associations and use network analysis to highlight biological pathways.

Cecilia Lindgren and colleagues report results of a large-scale genome-wide association study for waist-to-hip ratio, a measure of body fat distribution. They identify 13 new loci associated with this trait, several of which show stronger effects in women than in men.

Lampreys, an ancient vertebrate lineage, can provide unique insights into early retinal evolution. Using scRNA-seq and computational analysis, this study compared retinal cell types between lamprey and jawed species, illuminating retinal cell origins and diversification.

The role of MYC in transcriptional reprogramming in prostate cancer remains poorly characterized. Here, MYC overexpression antagonizes the canonical AR transcriptional program leading to prostate tumor initiation and progression by disrupting transcriptional pause release at AR-regulated genes.

Patients with BRAF^V600E-mutated colorectal cancer have encouraging overall response rates to inhibition of PD-1, BRAF and MEK, with translational analyses suggesting that induction of tumor-intrinsic programs and immune programs contributes to improved outcomes via MAPK inhibition.

The emergence of two dimensional ferromagnetism suffers from an inherent fragility to thermal fluctuations, which typically restricts the Curie temperature to below room temperature. Here, Zhang et al present CrTe₂ thin films grown via molecular beam epitaxy with a Curie temperature exceeding 300 K.

Most eukaryotes maintain telomeres using a specialized reverse transcriptase. Here the authors report that Thc1 (Telomerase Holoenzyme Component 1) and Bmc1 (Bin3/MePCE 1) form a complex with Pof8, a constitutive member of telomerase in fission yeast.

Theoretically predicted in 1979, hyper-Raman optical activity is now experimentally observed through chirality conferral from the electromagnetic field of chiral plasmonic gold nanohelices to crystal violet molecules that are achiral, sparking new science at the organic–inorganic interface.

Microbial communities drive all biogeochemical processes on Earth through spatiotemporal resource partitioning. This study shows how a few mutations in an evolved community can result in niche-differentiated ecotypes, whose interplay synergistically improves productivity of the interacting community across sediment and groundwater subpopulations.

Activation of nested, but not discrete, neural circuits drives alternative courtship songs in male Drosophila melanogaster, providing further insight into how the nervous system can drive the same motor systems to rapidly switch between different actions.

Esophageal adenocarcinoma is characterised by frequent amplifications in oncogenes. Here, the authors use short- and long-read sequencing approaches to analyze primary tumor samples and tumour-derived organoids and to investigate the mechanisms underlying complex amplifications.

Clones expressing variants of the X-chromosome-linked STAG2 gene only form lymphocytes in the absence of Stag2^WT clones. Interactions between epigenetic clones can thus modulate the impact of X-chromosome-linked genetic diversity in a cell-type-specific manner.

Using highly purified protein factors, we provide evidence that BRCA1–BARD1 physically interacts with EXO1, BLM and WRN and upregulates the activity of all three resection pathways.

Tracking single molecule movements is a challenging task, but highly desired for applications and fundamental studies. Here the authors reconstruct the sub-angstrom relative movements of a molecule interacting with a metal adatom, by measuring its vibrational spectrum in a self-assembled monolayer, continuously modified by the adatom in a nanoparticle-on-mirror construct.

Using metal anodes could in principle boost the energy density of batteries but their electrodeposition often negatively impacts battery performance. Here the authors propose an oxygen-mediated metal–substrate bonding strategy to regulate metal deposition and demonstrate highly reversible Al and Zn anodes.

Identification of a hyperstable boronate enables automated lego-like synthesis to access a wider range of three-dimensionally complex small organic molecules rich in Csp³–C bonds. 

Phenotypic and genetic heterogeneity of cells within a tumour is thought to mediate treatment resistance and contribute to cancer progression. Here the authors show that genetic diversity in pediatric cancers is common after chemotherapy and can be quantified to predict survival.

Guaianolides are pharmaceutically interesting molecules. Here, the authors isolate the enzyme kauniolide synthase from feverfew, show that it converts constunolide into a guaianolide via an unusual mechanism of action, and reconstruct the full kauniolide biosynthesis pathway in host organisms.

Massively parallel but cost-effective testing is essential to monitor the spread of pathogenic agents. Here the authors present SARSseq, which uses a dual indexing strategy in a multiplexed RT-PCR reaction to diagnose SARS-CoV-2 at scale.

Interferon-ε is a tumour suppressor expressed in the epithelial cell of origin of ovarian cancer, which it restricts by direct action on tumour cells and especially by activation of anti-tumour immunity.

Acclimation of tree photosynthesis to warming may be affected by elevated CO₂. Here, the authors show that mature boreal conifers may be able to maintain leaf-level C uptake under warming and elevated CO₂ even if optimum temperature of photosynthesis does not track increased temperature.

In this work, the authors combine cryo-electron tomography of vitrified virions, mass spectrometry, modeling, molecular dynamics and infectivity assay and report that a hinge glycan on viral spike protein influences virus infection and immune evasion.