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Showing 1–3 of 3 results
Advanced filters: Author: David Tareste Clear advanced filters

  • The SNARE-binding protein complexin (CPX) can both facilitate and inhibit membrane fusion, which has been puzzling. Using the Surface Forces Apparatus (SFA) system to obtain distance and interaction measurements of SNARE complexes assembling between bilayers demonstrates that CPX stabilizes an intermediate energetic state in which the SNAREpins are half-zippered, explaining activation and inhibition as the dual consequences of this single mechanism of action.

    • Feng Li
    • Frédéric Pincet
    • James E Rothman
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 941-946

  • The surface area of neurons increases rapidly during neurite extension. Galli and colleagues show that the endoplasmic reticulum (ER)-resident SNARE protein Sec22b bridges the ER and plasma membrane during this process and contributes to plasma membrane expansion, but does not promote membrane fusion.

    • Maja Petkovic
    • Aymen Jemaiel
    • Thierry Galli
    Research
    Nature Cell Biology
    Volume: 16, P: 434-444