Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–8 of 8 results
Advanced filters: Author: David Van Vactor Clear advanced filters

  • Although micro(mi)RNA-based post-transcriptional regulatory mechanisms have been implicated in the assembly and modulation of synaptic connections, few miRNAs have been identified that control synapse formation. Here, authors performed an unbiased screen for novel regulators of synapse morphogenesis at the Drosophila larval neuromuscular junction and discovered that miR-34 inhibits Nrx-IV to influence active zone formation, whereas, postsynaptic miR-34 inhibits Hts to regulate the initiation of bouton formation from presynaptic terminals.

    • Elizabeth M. McNeill
    • Chloe Warinner
    • David Van Vactor
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • The journey of the growth cone is similar to a vehicle on a road. Cytoskeletal elements form the 'motor' to move forward and provide traction on the road, whereas a 'navigator' system guides the vehicle to translate environmental signals into directional movement.

    • Laura Anne Lowery
    • David Van Vactor
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 10, P: 332-343

  • Transgenic RNA ‘sponges’ that inhibit specific microRNAs are valuable tools for functional studies. Fulga et al. present a library of conditional microRNA sponges in Drosophila, and reveal widespread involvement of microRNAs in the maintenance of adult muscle structure and function.

    • Tudor A. Fulga
    • Elizabeth M. McNeill
    • David Van Vactor
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10

  • The molecular pathways involved in wiring the brain have just begun to be elucidated. Work in this issue of Nature Cell Biology has uncovered inhibitory interactions between two such pathways: Roundabout (Robo) and N-Cadherin. This discovery provides a potential mechanistic understanding of how pathways are used in a coordinated manner to guide axons.

    • Mark M. Emerson
    • David Van Vactor
    News & Views
    Nature Cell Biology
    Volume: 4, P: E227-E229