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Showing 1–4 of 4 results
Advanced filters: Author: Davide Eletto Clear advanced filters

  • JAK1 mediates intracellular signalling from multiple cytokine receptors. Here, Elettoet al. identify JAK1 mutations that disrupt multiple signalling pathways and are associated with primary immunodeficiency, atypical mycobacterial infection susceptibility and early-onset metastatic bladder carcinoma.

    • Davide Eletto
    • Siobhan O. Burns
    • Sergey Nejentsev
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12

  • Polymorphisms in the avian influenza A virus (IAV) polymerase restrict its host range during transmission from birds to mammals. Here, the authors investigate differences in the host chromatin regulator ANP32A regarding IAV polymerase adaptation, and profile ANP32A splicing to predict avian species associated with pre-adaptive human-signatures in the virus.

    • Patricia Domingues
    • Davide Eletto
    • Benjamin G. Hale
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12