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Showing 1–12 of 12 results
Advanced filters: Author: Dean Kos Clear advanced filters

  • DNA methylation is a repressive modification that is essential for development. Here the authors reveal a critical role for DNA methylation in placental development during pregnancy. Failure to properly establish placental DNA methylation patterns compromises not only placental function, but embryo survival.

    • Simon Andrews
    • Christel Krueger
    • Courtney W. Hanna
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • The role of TRPV1 in the CNS is not fully understood. Here the authors show that TRPV1 is expressed specifically in somatostatin-positive OLM interneurons of the hippocampus, where it promotes excitatory innervation of these cells.

    • Joaquin I. Hurtado-Zavala
    • Binu Ramachandran
    • Camin Dean
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-20

  • Attenuating effects of the ketogenic diet on colorectal cancer (CRC) cell growth has been previously described. Here, using a mouse model of CRC with a humanized microbiome, the authors identify a shift toward gut bacterial species that produce stearic acid in ketogenic conditions, resulting in elevated levels of free stearate in the gut lumen, which they then show exhibits tumor-suppressing properties.

    • Mina Tsenkova
    • Madita Brauer
    • Elisabeth Letellier
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • The development of molecular electronics at single molecule level calls for new tools beyond electrical characterisation. Kos et al. show an optical probe of molecular junctions in a plasmonic nanocavity geometry, which supports in situ interrogation of molecular configurations.

    • Dean Kos
    • Giuliana Di Martino
    • Jeremy J. Baumberg
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-8

  • Here, the authors report the coupling between a single dye molecule and plasmonic nanocavity at room temperature. They provide insight into the statistical properties of the emission and observe non-classical emission, with photon bunching and anti-bunching regimes dependent on the excitation wavelength.

    • Oluwafemi S. Ojambati
    • Rohit Chikkaraddy
    • Jeremy J. Baumberg
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-7

  • A nanoplasmonic technique was used to investigate in operando the switching properties of materials used in redox random access memories, providing insight into the operation and potential breakdown mechanisms of the devices.

    • Giuliana Di Martino
    • Angela Demetriadou
    • Jeremy J. Baumberg
    Research
    Nature Electronics
    Volume: 3, P: 687-693

  • Diagnosis of dyslipidemia currently relies on calculating LDL cholesterol concentration, a strategy with limitations that can lead to underestimation of the patient's lipid levels and, consequently, their cardiovascular risk. In this Viewpoint, James Stein and Patrick McBride discuss how alternative options for characterizing dyslipidemia, such as measurement of apoplipoprotein B-100 and non-HDL cholesterol, and determining LDL particle size by nuclear magnetic resonance spectroscopy, could have clinical application.

    • James H Stein
    • Patrick E McBride
    Reviews
    Nature Clinical Practice Cardiovascular Medicine
    Volume: 3, P: 640-641

  • Two-dimensional materials offer the prospect of excitonic devices operating at room-temperature. Here, Kleemann et al. demonstrate that by tuning the number of WSe2 layers in a nanoparticle-on-mirror geometry, room-temperature plasmon strong-coupling can be achieved with large Rabi splittings.

    • Marie-Elena Kleemann
    • Rohit Chikkaraddy
    • Jeremy J. Baumberg
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-7

  • The cardiovascular benefits of statin therapy are well documented; however, no trial has identified a target level for LDL cholesterol below which no further benefit of treatment is seen. With the introduction of more-aggressive optional LDL-cholesterol targets in US guidelines, Antonio Gotto and John Farmer consider the rationale for combination therapy of statins with the cholesterol absorption inhibitor ezetimibe.

    • Antonio M Gotto Jr
    • John A Farmer
    Reviews
    Nature Clinical Practice Cardiovascular Medicine
    Volume: 3, P: 664-672