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Showing 1–6 of 6 results
Advanced filters: Author: Dean P. Staus Clear advanced filters

  • A newly developed maternally selective nanobody antagonist against the angiotensin II type I receptor stabilizes the receptor in a hybrid conformation and simultaneously binds with specific small-molecule antagonists.

    • Meredith A. Skiba
    • Sarah M. Sterling
    • Andrew C. Kruse
    Research
    Nature Chemical Biology
    Volume: 20, P: 1577-1585

  • Evolution of RNA aptamers that act allosterically by recognizing and stabilizing specific conformations, including active, inactive, and ligand-specific conformations of the GPCR β2-adrenergic receptor, bound to pharmacologically distinct ligands.

    • Alem W Kahsai
    • James W Wisler
    • Robert J Lefkowitz
    Research
    Nature Chemical Biology
    Volume: 12, P: 709-716

  • β1 and β2 adrenergic receptors (ARs) are the predominant G protein-coupled receptor subtypes expressed in mammalian hearts. Here the authors describe a signaling mechanism where the biased agonist carvedilol converts β1AR from a classical Gαs-coupled to a Gαi-coupled receptor to mediate β-arrestin-dependent signaling.

    • Jialu Wang
    • Kenji Hanada
    • Howard A. Rockman
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • The crystal structure of β-arrestin-1 in complex with a fully phosphorylated 29-amino-acid carboxy-terminal peptide derived from the V2 vasopressin receptor is reported; the structure of the complex shows striking conformational differences in β-arrestin-1 when compared with its inactive conformation.

    • Arun K. Shukla
    • Aashish Manglik
    • Robert J. Lefkowitz
    Research
    Nature
    Volume: 497, P: 137-141