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Showing 1–7 of 7 results
Advanced filters: Author: Dean Scholl Clear advanced filters

  • Coordination of benzene by a tungsten complex can minimize the formation of oligomeric aromatic products in Friedel-Crafts Arylation. Here the authors show that coordinating benzene to tungsten through two carbons (dihapto-coordination) enables a rarely observed double protonation of the bound benzene, allowing its subsequent coupling to a second arene without the need of a precious metal or Lewis acid catalyst.

    • Justin T. Weatherford-Pratt
    • Jacob A. Smith
    • W. Dean Harman
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-8

  • The authors report near-atomic resolution structures of the R-type bacteriocin from Pseudomonas aeruginosa in the pre-contraction and post-contraction states, and these structures provide insight into the mechanism of action of molecular syringes.

    • Peng Ge
    • Dean Scholl
    • Z. Hong Zhou
    Research
    Nature
    Volume: 580, P: 658-662

  • R-type contractile bacteriocins are natural-occurring nanomachines that kill bacteria. Here the authors report the atomic structures of a bacteriocin, called diffocin, that has been engineered to kill Gram-positive bacterium Clostridioides difficile.

    • Xiaoying Cai
    • Yao He
    • Z. Hong Zhou
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Unlike the involvement of the synaptotagmin (syt) family of proteins in calcium-triggered membrane fusion, the precise function and localization of syt-IV are not clear. Here the authors demonstrate that syt-IV is present in BDNF-containing vesicles and regulates axonal/dendritic release of BDNF, which in turn modulates long-term potentiation in hippocampal neurons.

    • Camin Dean
    • Huisheng Liu
    • Edwin R Chapman
    Research
    Nature Neuroscience
    Volume: 12, P: 767-776