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Showing 1–4 of 4 results
Advanced filters: Author: Deanna Saylor Clear advanced filters

  • Despite highly effective combination antiretroviral therapies, the prevalence of HIV-associated neurocognitive disorder (HAND) has not reduced. To date, clinical trials of HAND therapies have been unsuccessful, calling for better understanding of HAND pathogenesis to develop more-effective treatment strategies. In this Review, Justin McArthur and colleagues discuss recent proceedings in understanding the immunopathogenesis of HAND, drawing from human studies and animal models.

    • Deanna Saylor
    • Alex M. Dickens
    • Justin C. McArthur
    Reviews
    Nature Reviews Neurology
    Volume: 12, P: 234-248

  • Current approaches to classifying cognitive impairment in people living with HIV can overestimate disease burden and lead to ambiguity around disease mechanisms. In this Consensus Statement, the International HIV-Cognition Working Group have outlined six recommendations towards a new approach, intended to better represent changes in the spectrum of HIV disease in the modern era of antiretroviral therapy.

    • Sam Nightingale
    • Beau Ances
    • Alan Winston
    Reviews
    Nature Reviews Neurology
    Volume: 19, P: 424-433