Immunoglobulin class switch recombination requires the activity of the RNA-degrading enzyme DIS3, and mutations affecting DIS3 exoribonucleolytic activity are common in multiple myeloma, implying that these dominant variants could be causal to B lymphoid tumorigenesis. Here the authors generate knock-in mice carrying the human DIS3 G766R mutation, which leads to plasmacytoid tumorigenesis via impairing the precision of AID-targeting.
- Tomasz M. Kuliński
- Olga Gewartowska
- Andrzej Dziembowski
