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Showing 1–4 of 4 results
Advanced filters: Author: Debasish Raha Clear advanced filters

  • A description is given of the ENCODE consortium’s efforts to examine the principles of human transcriptional regulatory networks; the results are integrated with other genomic information to form a hierarchical meta-network where different levels have distinct properties.

    • Mark B. Gerstein
    • Anshul Kundaje
    • Michael Snyder
    ResearchOpen Access
    Nature
    Volume: 489, P: 91-100

  • This overview of the ENCODE project outlines the data accumulated so far, revealing that 80% of the human genome now has at least one biochemical function assigned to it; the newly identified functional elements should aid the interpretation of results of genome-wide association studies, as many correspond to sites of association with human disease.

    • Ian Dunham
    • Anshul Kundaje
    • Ewan Birney
    ResearchOpen Access
    Nature
    Volume: 489, P: 57-74

  • Genome wide analysis of human RNA Polymerase III (Pol) reveals both known and new targets of Pol III, with many of the latter binding regions found near SINEs. Active Pol III genes are near active Pol II promoters, whereas inactive Pol III genes are not. ETC loci, which are bound by TFIIIC but not TFIIIB and Pol III, are near active Pol II promoters and CTCF binding sites.

    • Zarmik Moqtaderi
    • Jie Wang
    • Kevin Struhl
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 635-640