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Showing 1–10 of 10 results
Advanced filters: Author: Deborah S. Wuttke Clear advanced filters

  • Urinary albumin-to-creatinine ratio (UCAR) is associated with various clinical outcomes such as kidney disease and cardiovascular disease. Here, the authors report genome-wide meta-analysis in over 500,000 individuals and find 68 UACR loci, followed by statistical fine-mapping, gene prioritization and experimental validation in flies.

    • Alexander Teumer
    • Yong Li
    • Anna Köttgen
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-19

  • A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

    • Loïc Yengo
    • Sailaja Vedantam
    • Joel N. Hirschhorn
    ResearchOpen Access
    Nature
    Volume: 610, P: 704-712

  • A trans-ancestry genome-wide association study of serum urate levels identifies 183 loci influencing this trait. Enrichment analyses, fine-mapping and colocalization with gene expression in 47 tissues implicate the kidney and liver as key target organs and prioritize potential causal genes.

    • Adrienne Tin
    • Jonathan Marten
    • Anna Köttgen
    Research
    Nature Genetics
    Volume: 51, P: 1459-1474

  • The three N-terminal zinc fingers of transcription factor IIIA bind in the DNA major groove. Substantial packing interfaces are formed between adjacent fingers, the linkers lose their intrinsic flexibility upon DNA binding, and several lysine side chains implicated in DNA recognition are dynamically disordered.

    • Mark P. Foster
    • Deborah S. Wuttke
    • Peter E. Wright
    Correspondence
    Nature Structural Biology
    Volume: 4, P: 605-608

  • Some transcription factors have been proposed to functionally interact with RNA to facilitate proper regulation of gene expression. Here the authors demonstrate that human Sox2 interact directly and with high affinity to RNAs through its HMG DNA-binding domain.

    • Zachariah E. Holmes
    • Desmond J. Hamilton
    • Robert T. Batey
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • CST is both an ssDNA-binding complex and a DNA Pol-α/primase cofactor that coordinates the switch from G-strand elongation to C-strand fill-in during telomere maintenance. Four papers in Nature Structural & Molecular Biology and Nature provide transformative insights into CST activity, providing a platform to understand lagging-strand synthesis genome wide.

    • Conner L. Olson
    • Alexandra T. Barbour
    • Deborah S. Wuttke
    News & Views
    Nature Structural & Molecular Biology
    Volume: 29, P: 730-733